SynthesisHuman brain mapping2013
Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.
Synthesis in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Neural Blueprint of Novelty: A Meta-Analytic Dissection of Active and Passive Novelty Processing Networks.Brain and behavior · 2026Pooled it
- Neural activity during working memory encoding, maintenance, and retrieval: A network-based model and meta-analysis.Human brain mapping · 2019Pooled it
- Brain regions that show repetition suppression and enhancement: A meta-analysis of 137 neuroimaging experiments.Human brain mapping · 2017Pooled it
- Dopamine Enhances Item Novelty Detection via Hippocampal and Associative Recall via Left Lateral Prefrontal Cortex Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.Science translational medicine · 2019Trial
- Relationship between fMRI response during a nonverbal memory task and marijuana use in college students.Drug and alcohol dependence · 2018Trial
- Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence.Social cognitive and affective neuroscience · 2017Trial
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Old-New Recognition Memory Revisited.bioRxiv : the preprint server for biology · 2025Article
- Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal OlderThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping.Cell reports · 2025Article
- Article
- Neural subnetwork signatures distinguishing source and item memory retrieval: A meta-analysis of 66 fMRI studies.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Prior memory responses modulate behavior and brain state engagement.Communications psychology · 2024Article
- Parietal memory network and memory encoding versus retrieval impairments in PD-MCI patients: A hippocampal volume and cortical thickness study.CNS neuroscience & therapeutics · 2024Article
- Predictors of long-term memory and network connectivity 10 years after anterior temporal lobe resection.Epilepsia · 2024Article
- Have you been there before? Decoding recognition of spatial scenes from fMRI signals in precuneus.Human brain mapping · 2024Article
- Dissociable Contributions of the Medial Parietal Cortex to Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Investigating the effect of hippocampal sclerosis on parietal memory network.Epilepsia open · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents a meta-analysis comparing hit and correct rejection (CR) conditions across 48 fMRI studies. Old/new (hit > CR) effects associated most consistently with (1) components of the default-mode network, including the left angular gyrus, bilateral precuneus, and bilateral posterior cingulate regions, which may support the mental re-experiencing of an old event, or ecphory; (2) components of the cognitive-control network, involving the left dorsolateral and dorsomedial prefrontal cortex and bilateral intraparietal sulcus regions, which may mediate memory and non-memory control functions; and (3) the caudate nucleus, a key part of the brain's reward system that may support the satisfaction tied to target-detection. Direct comparisons of old/new effects between item versus source retrieval and "remember" versus "know" retrieval yielded three main sets of findings. First, default-mode network regions showed greater old/new effects in conditions associated with richer ecphoric processing. Second, cognitive-control network regions showed greater old/new effects in conditions associated with a greater demand for strategic-retrieval processing. Third, the caudate nucleus showed greater old/new effects in conditions tied to greater confidence in target-detection. New/old (CR > hit) effects most strongly associated with the bilateral medial temporal lobe, possibly reflecting greater encoding-related activity for new than for old items, and the right posterior middle temporal regions, possibly reflecting repetition-related neural priming for old items. In conclusion, neural activity distinguishing old from new events comprises an ensemble of multiple memory-specific activities, including encoding, retrieval, and priming, as well as multiple types of more general cognitive activities, including default-mode, cognitive-control, and reward processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.