ArticleHuman brain mapping2013
Measuring extrastriatal dopamine release during a reward learning task.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
- Effects of stress-induced inflammation on reward processing in healthy young women.Brain, behavior, and immunity · 2020Trial
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- A midbrain-cortical circuit mediated by a claustrum neuronal ensemble orchestrates drug-paired context memory processing.The Journal of clinical investigation · 2026Article
- Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Review
- Increased cortical structural covariance correlates with anhedonia in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain.Pain medicine (Malden, Mass.) · 2021Article
- Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- PET Imaging of Dopamine Neurotransmission During EEG Neurofeedback.Frontiers in physiology · 2020Article
- Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.Schizophrenia bulletin · 2019Article
- Depression genetic risk score is associated with anhedonia-related markers across units of analysis.Translational psychiatry · 2019Article
- Experimental sleep disruption and reward learning: moderating role of positive affect responses.Sleep · 2019Article
- Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia.Psychopharmacology · 2018Article
- Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [Biological psychiatry · 2018Article
- Evidence of a diurnal rhythm in implicit reward learning.Chronobiology international · 2018Article
- Brain Activity and Functional Connectivity Associated with Hypnosis.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Neuroclinical Framework for the Role of Stress in Addiction.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Assessing anhedonia in depression: Potentials and pitfalls.Neuroscience and biobehavioral reviews · 2016Review
- Intermittent Theta Burst Stimulation Increases Reward Responsiveness in Individuals with Higher Hedonic Capacity.Frontiers in human neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesReward learning is critical for survival. Animal research emphasizes the role of dopaminergic (DA) mesocorticolimbic pathways in reward learning, but few studies have evaluated extrastriatal DA functioning in humans. The purpose of this study was to examine presynaptic DA release in extrastriatal regions of the reward circuit by measuring displacement of the high affinity D(2) /D(3) radioligand [(18) F]Fallypride during a reward task.
designTen healthy volunteers underwent a [(18) F]Fallypride positron emission tomography protocol while performing a reward task, allowing us to assess participants' ability to modulate behavior as a function of reward. DA receptor ligand displacement was correlated with task performance and self-reported anhedonia. OBSERVATIONS: Parametric t-maps revealed significant decrease in [(18) F]Fallypride binding in the medial orbitofrontal cortex (mOFC), ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC), indicating endogenous DA release in these regions. Increasing anhedonic symptoms correlated with DA release in the left vmPFC, left dACC, and right dACC emerged (all r's > 0.65, P's < 0.05). Similarly, reduced reward learning correlated with higher DA release in left vmPFC, right vmPFC, and left dACC (all r's < -0.64, P's < 0.05). Left dACC (r = 0.66, P = 0.04) and left vmPFC (r = 0.74, P = 0.01) DA release showed a significant positive correlation with impaired tendency to modulate behavior as a function of prior positive reinforcements.
conclusionsThese findings support the hypothesis that DA release in mOFC, vmPFC, and dACC regions plays an important role in reinforcement learning in the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.