ArticleHuman brain mapping2013
Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Pooled it
- White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia.Neurorehabilitation and neural repair · 2021Trial
- Disrupted interhemispheric communication in primary progressive aphasia: a multimodal MRI study of homotopic connectivity.NeuroImage. Clinical · 2026Article
- FDG-PET in the Evaluation of Primary Progressive Aphasia: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- White Matter Hyperintensities in Behavioral Variant Frontotemporal Dementia and Semantic Variant Primary Progressive Aphasia.Neurology open access · 2026Article
- Fixel-based analysis reveals detailed white matter changes in semantic dementia.Brain structure & function · 2026Article
- Longitudinal evaluation of common and unique brain-networks in variants of primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia.Journal of neurology · 2025Article
- Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study.Alzheimer's research & therapy · 2024Article
- The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.Alzheimer's research & therapy · 2023Article
- The right hemisphere's capacity for language: evidence from primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural correlates of verbal fluency revealed by longitudinal T1, T2 and FLAIR imaging in stroke.NeuroImage. Clinical · 2023Article
- White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation.Brain and behavior · 2022Article
- Application of the dual stream model to neurodegenerative disease: Evidence from a multivariate classification tool in primary progressive aphasia.Aphasiology · 2022Article
- Right uncinate fasciculus supports socioemotional sensitivity in health and neurodegenerative disease.NeuroImage. Clinical · 2022Article
- The Role of White Matter Dysfunction and Leukoencephalopathy/Leukodystrophy Genes in the Aetiology of Frontotemporal Dementias: Implications for Novel Approaches to Therapeutics.International journal of molecular sciences · 2021Review
- Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.Neurobiology of disease · 2020Review
- How the speed of word finding depends on ventral tract integrity in primary progressive aphasia.NeuroImage. Clinical · 2020Article
- Article
- Hereditary primary lateral sclerosis and progressive nonfluent aphasia.Journal of neurology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Semantic (svPPA) and nonfluent (nfPPA) variants of primary progressive aphasia are associated with distinct patterns of cortical atrophy and underlying pathology. Little is known, however, about their contrasting spread of white matter disruption and how this relates to grey matter (GM) loss. We undertook a structural MRI study to investigate this relationship. We used diffusion tensor imaging, tract-based spatial statistics, and voxel-based morphometry to examine fractional anisotropy (FA) and directional diffusivities in nine patients with svPPA and nine patients with nfPPA, and compared them to 16 matched controls after accounting for global GM atrophy. Significant differences in topography of white matter changes were found, with more ventral involvement in svPPA patients and more widespread frontal involvement in nfPPA individuals. However, each group had both ventral and dorsal tract changes, and both showed spread of diffusion abnormalities beyond sites of local atrophy. There was a clear dissociation in sensitivity of diffusion tensor imaging measures between groups. SvPPA patients showed widespread changes in FA and radial diffusivity, whereas changes in axial diffusivity were more restricted and proximal to sites of GM atrophy. NfPPA patients showed isolated changes in FA, but widespread axial and radial diffusivity changes. These findings reveal the extent of white matter disruption in these variants of PPA after accounting for GM loss. Further, they suggest that differences in the relative sensitivity of diffusion metrics may reflect differences in the nature of underlying white matter pathology in these two subtypes.
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