ArticleJapanese journal of ophthalmology2012
Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands.
Article in Japanese journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- The role of childhood overweight in meibomian gland dysfunction and dry eye disease in Chinese children.BMC ophthalmology · 2025Article
- Crosslinking of tarsal collagen as a hypothetical therapy for dry eye disease.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Meibomian gland atrophy in children with allergic conjunctivitis.International journal of ophthalmology · 2025Article
- Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm.Frontiers in cell and developmental biology · 2024Article
- Evaluation of the meibomian glands using the tear interferometer wearing orthokeratology lenses.BMC ophthalmology · 2022Article
- Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis.Journal of clinical medicine · 2022Article
- 2D Short-Time Fourier Transform for local morphological analysis of meibomian gland images.PloS one · 2022Article
- Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Evaluation of the Ocular Surface and Meibomian Gland in Obstructive Sleep Apnea Hypopnea Syndrome.Frontiers in medicine · 2022Article
- Topographic and specular microscopic evaluation of cornea and meibomian gland morphology in children with isolated growth hormone deficiency.International ophthalmology · 2021Article
- Meibomian Gland Morphology Among Patients Presenting for Refractive Surgery Evaluation.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Meibomian gland dysfunction and dry eye in keratoconus.Arquivos brasileiros de oftalmologia · 2021Article
- Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study.The ocular surface · 2020Article
- A Novel Quantitative Index of Meibomian Gland Dysfunction, the Meibomian Gland Tortuosity.Translational vision science & technology · 2020Article
- The Role of Meibography in the Diagnosis of Meibomian Gland Dysfunction in Ocular Surface Diseases.Translational vision science & technology · 2019Article
- Grading and baseline characteristics of meibomian glands in meibography images and their clinical associations in the Dry Eye Assessment and Management (DREAM) study.The ocular surface · 2019Article
- Article
- Growth of meibomian gland tissue after intraductal meibomian gland probing in patients with obstructive meibomian gland dysfunction.The British journal of ophthalmology · 2018Article
- Ocular surface inflammation impairs structure and function of meibomian gland.Experimental eye research · 2017Review
- Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo observe morphological changes in the meibomian glands of patients with contact lens-related allergic conjunctivitis (CLAC) and to assess the relations between the morphological changes and eyelid and tear film parameters.
methodsWe observed subjects in four groups: 64 eyes of 64 contact lens (CL) wearers with CLAC, 77 eyes of 77 CL wearers without CLAC, 55 eyes of 55 patients with perennial allergic conjunctivitis (perennial AC), and 47 eyes of 47 healthy volunteers. The following tests were performed: slit-lamp examination, measurement of tear film breakup time, grading of morphological changes in meibomian glands (meiboscore) as assessed by noncontact meibography, grading of meibomian gland distortion in meibography, tear production as assessed by Schirmer's I test, and grading of meibum expression.
resultsThe mean score for meibomian gland distortion was significantly higher in the CL wearers with CLAC than in the CL wearers without CLAC (p < 0.0001); it was also significantly higher in the non-CL wearers with perennial AC than in the non-CL wearers without perennial AC (p < 0.0001). There was no significant difference between the mean scores for meibomian gland distortion of the non-CL wearers with perennial AC and the CL wearers with CLAC (p = 0.27). The score for meibomian gland distortion was significantly positively correlated with the meibum score in the CL wearers with CLAC and with the meiboscore in the CL wearers without CLAC.
conclusionCLAC is associated with an increase in meibomian gland distortion. Allergic reaction, rather than CL wear, appears to be responsible for the increase in meibomian gland distortion in patients with CLAC.
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