ArticleCerebral cortex (New York, N.Y. : 1991)2012
Longitudinal development of cortical and subcortical gray matter from birth to 2 years.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00877552 (Prospective Studies of the Pathogenesis of Schizophrenia), which is not on this map. Cited by 251 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Studies of the Pathogenesis of Schizophrenia (Center Title) Early Brain Development in High Risk Children (Project Title) Early Brain Development in One and Two Year Olds (Associated Grant Title)
Who cites it
251 citing papers in PubMed, 5 syntheses or guidelines pooled it, 464 citations in OpenAlex.
- The effect of antibiotics on the intestinal microbiota in children - a systematic review.Frontiers in allergy · 2024Pooled it
- Using machine learning to understand age and gender classification based on infant temperament.PloS one · 2022Pooled it
- Pooled it
- Neural correlates of socioeconomic status in early childhood: a systematic review of the literature.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Pooled it
- Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.Human brain mapping · 2017Pooled it
- Impact of a Nutrient Formulation on Longitudinal Myelination, Cognition, and Behavior from Birth to 2 Years: A Randomized Clinical Trial.Nutrients · 2023Trial
- Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism.bioRxiv : the preprint server for biology · 2026Article
- Maternal Childhood Neglect is Linked to Greater Infant Cortisol Levels and Larger Infant Limbic Volumes.Child maltreatment · 2026Article
- Surface expansion regionalization of the hippocampus in early brain development.Developmental cognitive neuroscience · 2026Article
- Early Relational Health and its Impact on the Developing Brain: A Scoping Review.Clinical child and family psychology review · 2026Article
- Understanding parental bonding in the first two years after birth: exploring family predictors using growth mixture modeling.BMC psychology · 2026Article
- Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes.bioRxiv : the preprint server for biology · 2026Article
- Role of Maternal Mindfulness in Longitudinal Mother-Infant Neuroendocrine Reciprocity in an Urban, Low-Income White Sample.Developmental psychobiology · 2026Article
- Family protective service involvement and reduced infant cortical grey matter volume.Infant mental health journal · 2026Article
- Altered spectral patterns of aperiodic electroencephalography in autism.Psychiatry and clinical neurosciences · 2026Article
- Increased CSF volume, altered brain development and emotional reactivity after postnatal Zika virus infection in infant rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin.PLoS biology · 2026Article
- Age-related volumetric differences of hippocampal subfields in the developing brain: a retrospective MRI study.Brain structure & function · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
191 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Very little is known about cortical development in the first years of life, a time of rapid cognitive development and risk for neurodevelopmental disorders. We studied regional cortical and subcortical gray matter volume growth in a group of 72 children who underwent magnetic resonance scanning after birth and at ages 1 and 2 years using a novel longitudinal registration/parcellation approach. Overall, cortical gray matter volumes increased substantially (106%) in the first year of life and less so in the second year (18%). We found marked regional differences in developmental rates, with primary motor and sensory cortices growing slower in the first year of life with association cortices growing more rapidly. In the second year of life, primary sensory regions continued to grow more slowly, while frontal and parietal regions developed relatively more quickly. The hippocampus grew less than other subcortical structures such as the amygdala and thalamus in the first year of life. It is likely that these patterns of regional gray matter growth reflect maturation and development of underlying function, as they are consistent with cognitive and functional development in the first years of life.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.