ArticleOptics express2011
Nonlinear structured illumination microscopy by surface plasmon enhanced stimulated emission depletion.
Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Superresolution structured illumination microscopy reconstruction algorithms: a review.Light, science & applications · 2023Review
- A method for the reconstruction of multifocal structured illumination microscopy data with high efficiency.Scientific reports · 2019Article
- Three-dimensional super-resolution high-throughput imaging by structured illumination STED microscopy.Optics express · 2018Article
- Continuous-Wave Stimulated Emission Depletion Microscope for Imaging Actin Cytoskeleton in Fixed and Live Cells.Sensors (Basel, Switzerland) · 2015Article
- Super-Resolution Scanning Laser Microscopy Based on Virtually Structured Detection.Critical reviews in biomedical engineering · 2015Review
- Cellular imaging of deep organ using two-photon Bessel light-sheet nonlinear structured illumination microscopy.Biomedical optics express · 2014Article
- Tuning donut profile for spatial resolution in stimulated emission depletion microscopy.The Review of scientific instruments · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Nonlinear structured illumination microscopy (SIM) in theory has unlimited resolution over a full field of view. However under a realistic signal-to-noise ratio and a limited photon budget, the performance of nonlinear SIM strongly depends on the behavior of the nonlinear effect. Saturated SIM (SSIM) is not ideal in biological applications due to its strong photobleaching. Stimulated emission depletion (STED) SIM will have high sensitivity, higher resolution and less photo toxicity than SSIM. However, the laser power necessary to support a strong full-field STED effect is not attainable with current laser technology. We experimentally proved that surface plasmon resonance enhances (SPR) near surface STED effect by a factor of 8, and therefore STED-SIM is feasible in the total internal reflection microscopy mode with SPR enhancement. Simulation analysis predicts that SPR enhanced 2D STED is strong enough for nonlinear SIM to achieve high-speed imaging at 30-nm resolution and single molecule sensitivity. The STED-SIM superresolution microscopy method would provide a solution for observing single molecule processes in vitro or on the basal membrane of live cells.
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Registered trials
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