ArticleOptics express2011
Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays.
Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Spatial Resolution and Refractive Index Contrast of Resonant Photonic Crystal Surfaces for Biosensing.IEEE photonics journal · 2015Article
- A fluorescent one-dimensional photonic crystal for label-free biosensing based on BLOCH surface waves.Sensors (Basel, Switzerland) · 2013Article
- Article
- Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.Journal of biophotonics · 2012Review
- Multiplexed cancer biomarker detection using quartz-based photonic crystal surfaces.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
By combining photonic crystal label-free biosensor imaging with photonic crystal enhanced fluorescence, it is possible to selectively enhance the fluorescence emission from regions of the PC surface based upon the density of immobilized capture molecules. A label-free image of the capture molecules enables determination of optimal coupling conditions of the laser used for fluorescence imaging of the photonic crystal surface on a pixel-by-pixel basis, allowing maximization of fluorescence enhancement factor from regions incorporating a biomolecule capture spot and minimization of background autofluorescence from areas between capture spots. This capability significantly improves the contrast of enhanced fluorescent images, and when applied to an antibody protein microarray, provides a substantial advantage over conventional fluorescence microscopy. Using the new approach, we demonstrate detection limits as low as 0.97 pg/ml for a representative protein biomarker in buffer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.