Evidence map›Paper›PMID 22109096›Full record

ArticleMicrobial ecology2012

Diketopiperazines produced by the halophilic archaeon, Haloterrigena hispanica, activate AHL bioreporters.

Giuseppina Tommonaro, Gennaro Roberto Abbamondi, Carmine Iodice, Karen Tait, Salvatore De Rosa

Abstract read
PubMed Publisher
In one paragraph

Article in Microbial ecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 86 citations in OpenAlex.

  1. First Evidence of Metabolically Active Intracellular Bacteria inJournal of agricultural and food chemistry · 2025
    Article
  2. Article
  3. Article
  4. Marine-Derived Furanones Targeting Quorum-Sensing Receptors inBioinformatics and biology insights · 2024
    Article
  5. Expression, purification, and enzymatic characterization of an extracellular protease from Halococcus salifodinae.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  6. Quorum Sensing inMicroorganisms · 2023
    Article
  7. Review
  8. Review
  9. Article
  10. TheApplied and environmental microbiology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Bioactive Potential of Extracts ofMolecules (Basel, Switzerland) · 2020
    Article
  18. ExtremophilicFrontiers in microbiology · 2020
    Article
  19. Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens.International journal of molecular sciences · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Giuseppina TommonaroInstitute of Biomolecular Chemistry, CNR-National Research Council of Italy, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy. gtommonaro@icb.cnr.it
Gennaro Roberto Abbamondi
Carmine Iodice
Karen Tait
Salvatore De Rosa
National Research Council · ITInstitute of Polymers, Composites and Biomaterials · ITNational Academies of Sciences, Engineering, and Medicine · USPlymouth Marine Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generic term "quorum sensing" has been adopted to describe the bacterial cell-to-cell communication mechanism which coordinates gene expression when the population has reached a high cell density. Quorum sensing depends on the synthesis of small molecules that diffuse in and out of bacterial cells. There are few reports about this mechanism in Archaea. We report the isolation and chemical characterization of small molecules belonging to class of diketopiperazines (DKPs) in Haloterrigena hispanica, an extremely halophilic archaeon. One of the DKPs isolated, the compound cyclo-(L-prolyl-L-valine) activated N-acyl homoserine lactone (AHL) bioreporters, indicating that Archaea may have the ability to interact with AHL-producing bacteria within mixed communities.

Indexed as

Signal TransductionAcyl-ButyrolactonesDiketopiperazinesEscherichia coliGenes, ReporterHalobacteriaceaeMolecular StructureSodium ChlorideAcyl-ButyrolactonesDiketopiperazinesSodium Chloride

Identifiers

PMID22109096
OpenAlexW2050109712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.