Evidence map›Paper›PMID 22108978›Full record

ArticleOptics express2011

Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex.

Jonghwan Lee, Vivek Srinivasan, Harsha Radhakrishnan, David A Boas

Open access · goldAbstract read
In one paragraph

Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jonghwan LeeMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA. jonghwan@nmr.mgh.harvard.edu
Vivek Srinivasan
Harsha Radhakrishnan
David A Boas
Harvard University · US

Funding

Spatiotemporal Brain Imaging: Microscopic &System LevelR01EB000790 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2002 to 2015
$15.3M
Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Non Ivasive Optical Imaging of the Human BrainR01EB001954 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA · 2004 to 2013
$3.2M
Multiscale Dynamic Measurements and Modeling of Cerebrovascular PhysiologyR01NS057476 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2007 to 2011
$2.0M
Functional Optical Coherence Tomography for Imaging of Cortical HemodynamicsK99NS067050 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SRINIVASAN, VIVEK JAY · 2009 to 2010
$180k
NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB000790NIBIB NIH HHS R01EB000790NIBIB NIH HHS R01 EB001954NIBIB NIH HHS R01-EB001954NINDS NIH HHS K99 NS067050NINDS NIH HHS K99NS067050NINDS NIH HHS P01 NS055104NINDS NIH HHS P01NS055104NINDS NIH HHS R01 NS057476NINDS NIH HHS R01NS057476
6 · The paper itself

Abstract

Cardiac and respiratory motions in animals are the primary source of image quality degradation in dynamic imaging studies, especially when using phase-resolved imaging modalities such as spectral-domain optical coherence tomography (SD-OCT), whose phase signal is very sensitive to movements of the sample. This study demonstrates a method with which to compensate for motion artifacts in dynamic SD-OCT imaging of the rodent cerebral cortex. We observed that respiratory and cardiac motions mainly caused, respectively, bulk image shifts (BISs) and global phase fluctuations (GPFs). A cross-correlation maximization-based shift correction algorithm was effective in suppressing BISs, while GPFs were significantly reduced by removing axial and lateral global phase variations. In addition, a non-origin-centered GPF correction algorithm was examined. Several combinations of these algorithms were tested to find an optimized approach that improved image stability from 0.5 to 0.8 in terms of the cross-correlation over 4 s of dynamic imaging, and reduced phase noise by two orders of magnitude in ~8% voxels.

Indexed as

ArtifactsAlgorithmsAnimalsCerebral CortexMovementRatsRats, Sprague-DawleyTomography, Optical Coherence

Identifiers

PMID22108978
PMCPMC3386793
OpenAlexW2118444227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.