ArticleMolecular systems biology2011
Structural and functional protein network analyses predict novel signaling functions for rhodopsin.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Analyzing of Molecular Networks for Human Diseases and Drug Discovery.Current topics in medicinal chemistry · 2018Review
- Simple and complex retinal dystrophies are associated with profoundly different disease networks.Scientific reports · 2017Article
- A Comprehensive View of the β-Arrestinome.Frontiers in endocrinology · 2017Article
- microRNA regulatory circuits in a mouse model of inherited retinal degeneration.Scientific reports · 2016Article
- Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.PLoS computational biology · 2015Article
- Protein and Signaling Networks in Vertebrate Photoreceptor Cells.Frontiers in molecular neuroscience · 2015Review
- Elution profile analysis of SDS-induced subcomplexes by quantitative mass spectrometry.Molecular & cellular proteomics : MCP · 2014Article
- Molecular complexes that direct rhodopsin transport to primary cilia.Progress in retinal and eye research · 2014Review
- Structural bioinformatics of the interactome.Annual review of biophysics · 2014Review
- Interaction of 4.1G and cGMP-gated channels in rod photoreceptor outer segments.Journal of cell science · 2013Article
- Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.Cell communication and signaling : CCS · 2013Article
- Isotope coded protein labeling coupled immunoprecipitation (ICPL-IP): a novel approach for quantitative protein complex analysis from native tissue.Molecular & cellular proteomics : MCP · 2013Article
- Molecular signatures of G-protein-coupled receptors.Nature · 2013Review
- A comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks.Frontiers in physiology · 2013Article
- Interface-resolved network of protein-protein interactions.PLoS computational biology · 2013Article
- Interactome3D: adding structural details to protein networks.Nature methods · 2013Article
- Popular computational methods to assess multiprotein complexes derived from label-free affinity purification and mass spectrometry (AP-MS) experiments.Molecular & cellular proteomics : MCP · 2013Review
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Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orchestration of signaling, photoreceptor structural integrity, and maintenance needed for mammalian vision remain enigmatic. By integrating three proteomic data sets, literature mining, computational analyses, and structural information, we have generated a multiscale signal transduction network linked to the visual G protein-coupled receptor (GPCR) rhodopsin, the major protein component of rod outer segments. This network was complemented by domain decomposition of protein-protein interactions and then qualified for mutually exclusive or mutually compatible interactions and ternary complex formation using structural data. The resulting information not only offers a comprehensive view of signal transduction induced by this GPCR but also suggests novel signaling routes to cytoskeleton dynamics and vesicular trafficking, predicting an important level of regulation through small GTPases. Further, it demonstrates a specific disease susceptibility of the core visual pathway due to the uniqueness of its components present mainly in the eye. As a comprehensive multiscale network, it can serve as a basis to elucidate the physiological principles of photoreceptor function, identify potential disease-associated genes and proteins, and guide the development of therapies that target specific branches of the signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.