Evidence map›Paper›PMID 22108730›Full record

ReviewHeart failure clinics2012

Role of oxidative stress in disease progression in Stage B, a pre-cursor of heart failure.

Arvind Bhimaraj, W H Wilson Tang

Abstract readReview
In one paragraph

Review in Heart failure clinics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  9. Article
  10. Oxygen: how do we stand it?.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Arvind BhimarajMethodist DeBakey Cardiology Associates, Smith Tower, 6550 Fannin, Suite 1901, Houston, TX 77030, USA.
W H Wilson Tang
Cleveland Clinic · USHouston Methodist · US

Funding

Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
NHLBI NIH HHS 1R01HL103931-01NHLBI NIH HHS R01 HL103931
6 · The paper itself

Abstract

Oxidative stress represents a persistent imbalance between the production and the compensation of reactive oxygen species. Though predominantly found in advanced heart failure, the most frequent "at-risk" condition has been associated with underlying oxidative stress. It is therefore conceivable that timely detection and early intervention to reduce oxidative stress processes provide an opportunity to prevent disease progression to overt heart failure. This article reviews the current understanding of the current evidence of oxidative stress involvement in the pathophysiology of human heart failure and its potential therapeutic interventions in patients with Stage A and B heart failure.

Indexed as

AnimalsDisease ProgressionHeart FailureHumansOxidative StressReactive Oxygen SpeciesReactive Oxygen Species

Identifiers

PMID22108730
PMCPMC3227012
OpenAlexW2040141316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.