Evidence map›Paper›PMID 22108672›Full record

ReviewNature reviews. Neuroscience2011

Normalization as a canonical neural computation.

Matteo Carandini, David J Heeger

Erratum issuedAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 885 papers.

0numbers the graph read from it
0cells of the map it votes in
885citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

885 citing papers in PubMed.

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  17. Reversibly Desensitising the Human Retina to Delay Saccadic Reaction Time for Diagnostic Prototyping.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  18. Imagine No Resources: Attention Is Selection and Normalization for Choice.Perspectives on psychological science : a journal of the Association for Psychological Science · 2026
    Article
  19. Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

825 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors.

Matteo CarandiniUCL Institute of Ophtalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK. m.carandini@ucl. ac.uk
David J Heeger

Funding

Temporal Dynamics of Visual Perception and AttentionR01EY019693 · NEI · NEW YORK UNIVERSITY · PI CARRASCO, MARISA · 2010 to 2022
$4.0M
Traveling waves in visual cortex during binocularrivalryR01EY016752 · NEI · NEW YORK UNIVERSITY · PI HEEGER, DAVID J · 2005 to 2009
$2.1M
Medical Research Council G0800791NEI NIH HHS R01 EY016752NEI NIH HHS R01‑EY016752NEI NIH HHS R01 EY019693NEI NIH HHS R01‑EY019693
6 · The paper itself

Abstract

There is increasing evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply similar operations to different problems. A promising candidate for such a computation is normalization, in which the responses of neurons are divided by a common factor that typically includes the summed activity of a pool of neurons. Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain regions. Normalization may underlie operations such as the representation of odours, the modulatory effects of visual attention, the encoding of value and the integration of multisensory information. Its presence in such a diversity of neural systems in multiple species, from invertebrates to mammals, suggests that it serves as a canonical neural computation.

Indexed as

Models, NeurologicalAdaptation, PhysiologicalAfferent PathwaysAnimalsAttentionHumansNeuronsPhotic StimulationVisual Cortex

Identifiers

PMID22108672
PMCPMC3273486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.