ArticleFEBS letters2011
Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.
Article in FEBS letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- DGKs in lipid signaling and disease intervention: structural basis, pathological mechanisms, and emerging therapeutic strategies.Cellular & molecular biology letters · 2025Review
- Article
- The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.Molecular biology of the cell · 2024Article
- Article
- Diacylglycerol Kinase Puts the Brakes on Airway Smooth Muscle Contraction.American journal of respiratory cell and molecular biology · 2021Article
- A rare cause of membranoproliferative patterns of injury in siblings with steroid-resistant nephrotic syndrome: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering.Nature chemical biology · 2020Article
- Roles of DGKs in neurons: Postsynaptic functions?Advances in biological regulation · 2020Review
- Diacylglycerol kinases: Relationship to other lipid kinases.Advances in biological regulation · 2019Review
- Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.Journal of lipid research · 2017Article
- Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.Scientific reports · 2017Article
- Arachidonoyl-Specific Diacylglycerol Kinase ε and the Endoplasmic Reticulum.Frontiers in cell and developmental biology · 2016Review
- Diacylglycerol Kinase-ε: Properties and Biological Roles.Frontiers in cell and developmental biology · 2016Review
- Podocyte dysfunction in atypical haemolytic uraemic syndrome.Nature reviews. Nephrology · 2015Review
- Distinct properties of the two isoforms of CDP-diacylglycerol synthase.Biochemistry · 2014Article
- Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.The Journal of biological chemistry · 2012Article
- Diacylglycerol kinases in membrane trafficking.Cellular logisticsReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We show that diacylglycerol kinase-ε (DGKε) has less preference for the acyl chain at the sn-1 position of diacylglycerol (DAG) than the one at the sn-2 position. Although DGKε discriminates between 1-stearoyl-2-arachidonoyl-DAG and 1-palmitoyl-2-arachidonoyl-DAG, it has similar substrate preference for 1-stearoyl-2-arachidonoyl-DAG and 1,2-diarachidonoyl-DAG. We suggest that in addition to binding to the enzyme, the acyl chain at the sn-1 position may contribute to the depth of insertion of the DAG into the membrane. Thus, the DAG intermediate of the PI-cycle, 1-stearoyl-2-arachidonoyl-DAG, is not the only DAG that is a good substrate for DGKε, the DGK isoform involved in PI-cycling.
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Registered trials
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