ReviewMelanoma research2012
Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model.
Review in Melanoma research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Which symptoms are linked to a delayed presentation among melanoma patients? A retrospective study.BMC cancer · 2017Trial
- Declining melanoma incidence among younger adults in Sweden: insights from histopathological subtypes and the role of immigration.Acta oncologica (Stockholm, Sweden) · 2026Article
- The impairment of CD3+ T lymphocytes in sentinel lymph node of high-risk cutaneous melanoma patients in stage IIB and IIC.Journal of pathology and translational medicine · 2026Article
- Article
- Translating Features to Findings: Deep Learning for Melanoma Subtype Prediction.Dermatopathology (Basel, Switzerland) · 2025Review
- Histopathological Subtypes of Cutaneous Melanoma: Prognostic and Molecular Implications.Cureus · 2025Review
- A descriptive review of common dermatological diseases encountered by manual therapy providers.The Journal of the Canadian Chiropractic Association · 2025Article
- Development of a prognostic model for patients with nodular melanoma of the lower extremities: a study based on the SEER database.Archives of dermatological research · 2024Article
- Article
- Artificial intelligence-assisted metastasis and prognosis model for patients with nodular melanoma.PloS one · 2024Article
- PredictingJournal of skin cancer · 2024Article
- Case report: Exceptional disease progression in a 70-year-old patient: generalized melanosis and melanuria in the course of metastatic melanoma - a case study.Frontiers in oncology · 2024Article
- Article
- Article
- Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study.Biomedicines · 2022Article
- Associations between TERT Promoter Mutations and Survival in Superficial Spreading and Nodular Melanomas in a Large Prospective Patient Cohort.The Journal of investigative dermatology · 2022Article
- Cutaneous melanoma incidence, mortality, and survival in Manizales, Colombia: a population-based study.The Journal of international medical research · 2022Article
- Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis.International journal of molecular sciences · 2022Review
- Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines.International journal of molecular sciences · 2022Article
- Loss of 'Epidermal Melanin Unit' Integrity in Human Skin During Melanoma-Genesis.Frontiers in oncology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The classification of melanoma subtypes into prognostically relevant and therapeutically insightful categories has been a challenge since the first description of melanoma in the 1800s. One limitation has been the assumption that the two most common histological subtypes of melanoma, superficial spreading and nodular, evolve according to a linear model of progression, as malignant melanocytes spread radially and then invade vertically. However, recent clinical, pathological, and molecular data indicate that these two histological subtypes might evolve as distinct entities. Here, we review the published data that support distinct molecular characterization of superficial spreading and nodular melanoma, the clinical significance of this distinction including prognostic relevance and the therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.