ArticleCell cycle (Georgetown, Tex.)2011
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- The Splicing Factor PTBP1 RepressesCancer research communications · 2022Article
- Molecular cloning, characterization and expression analysis of P53 from high latitude fish Phoxinus lagowskii and its response to hypoxia.Fish physiology and biochemistry · 2022Article
- Conservation and Divergence of p53 Oscillation Dynamics across Species.Cell systems · 2017Article
- Putting p53 in Context.Cell · 2017Review
- The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans.Genes & development · 2016Article
- Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.Protein science : a publication of the Protein Society · 2016Article
- Article
- p53 Acetylation: Regulation and Consequences.Cancers · 2014Review
- Tracing the evolution of the p53 tetramerization domain.Structure (London, England : 1993) · 2014Article
- Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.Chemical reviews · 2014Review
- ∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Oncotarget · 2014Article
- The MDM2 gene family.Biomolecular concepts · 2014Review
- Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53.Cell cycle (Georgetown, Tex.) · 2014Article
- MDMX contains an autoinhibitory sequence element.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network.Cell death and differentiation · 2013Article
- Intrinsically disordered regions of p53 family are highly diversified in evolution.Biochimica et biophysica acta · 2013Article
- Tissue-specific expression of p73 C-terminal isoforms in mice.Cell cycle (Georgetown, Tex.) · 2012Article
- Mdm2 in evolution.Genes & cancer · 2012Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the p19(Arf) gene. Detailed comparison of the amino acid sequences of these proteins in the vertebrates reveals that they are evolving at highly distinctive rates, and this variation occurs not only between the three family members but extends to distinct domains in each protein.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.