ArticleJournal of endocrinological investigation2012
Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria.
Article in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Habitual nutrient intakes and postprandial glycaemic responses to glucose and orange juice among ethnically diverse adults in London: an exploratory cross-sectional analysis.Frontiers in nutrition · 2026Article
- Nutritional intake of micronutrient and macronutrient and type 2 diabetes: machine learning schemes.Journal of health, population, and nutrition · 2025Article
- Interlinking the Cross Talk on Branched Chain Amino Acids, Water Soluble Vitamins and Adipokines in the Type 2 Diabetes Mellitus Etiology.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Correlation of Serum Sodium and Potassium With Thiamin Levels in Type 1 and Type 2 Diabetic Patients.Cureus · 2024Article
- Correlation of Blood Urea and Creatinine Levels With Thiamin Levels in Type 1 and Type 2 Diabetic Patients.Cureus · 2024Article
- Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients.Cureus · 2023Article
- Relationship Between Vitamins and Diabetes.Cureus · 2023Review
- The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.Nutrition & diabetes · 2022Article
- Unravelling theMolecules (Basel, Switzerland) · 2022Article
- Article
- Association of multiple mineral and vitamin B group intake with blood glucose using quantile regression analysis: NHANES 2007-2014.Food & nutrition research · 2019Article
- Activities of Lysosomal Enzymes in Alloxan-Induced Diabetes in the Mouse.Advances in experimental medicine and biology · 2018Article
- Diabetic cardiac autonomic neuropathy: Do we have any treatment perspectives?World journal of diabetes · 2015Review
- Article
- Biochemical changes correlated with blood thiamine and its phosphate esters levels in patients with diabetes type 1 (DMT1).International journal of clinical and experimental pathology · 2015 · on this mapArticle
- Vitamins and type 2 diabetes mellitus.Endocrine, metabolic & immune disorders drug targets · 2015Review
- Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2.Clinical medicine insights. Endocrinology and diabetes · 2014Article
- Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs.European journal of medical research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM). In this study, we aim to assess blood and urine thiamine status by high performance liquid chromatography (HPLC) in patients with DM Type 1 and Type 2 (DMT1, DMT2) and to identify associations with markers of incipient nephropathy and kidney dysfunction. SUBJECTS AND
methodsA total of 205 subjects (43 DMT1 and 162 DMT2) with and without microalbuminuria and 26 non-diabetic controls were included. Fasting blood samples were collected and anthropometric parameters were measured. Fasting blood, lipid and renal profile were determined routinely. Blood thiamine concentration, its phosphate esters and urine thiamine were quantified using HPLC.
resultsBlood thiamine concentrations (ng 1-1) were decreased by 75.7% and 49.6% in patients with DMT1 and DMT2, respectively [controls (54.8+/-11.4); DMT1 (41.5+/-17.9); DMT2 (27.2+/-12.7), p<0.001]. Among those with normo-albuminuria, urinary excretion of thiamine was significantly increased to 390.1 microg/ml and 1212.4 microg/ml in DMT1 and DMT2 respectively, as compared to controls (326.4 microg/ml). DMT1 and DMT2 patients with micro- albuminuria on the other hand had 2.5- and 3.4-fold increase in urinary excretion of thiamine compared to controls.
conclusionLow levels of blood thiamine are present in patients with DMT1 and DMT2, and are associated with increased thiamine clearance.
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