Evidence map›Paper›PMID 22107817›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2012

Effects of hepatitis C and HIV on cognition in women: data from the Women's Interagency HIV Study.

Howard Crystal, Inna Kleyman, Kathryn Anastos, Jason Lazar, Mardge Cohen, Chenglong Liu, Leigh Pearce, Elizabeth Golub, Victor Valcour, Ann Ho and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C.Journal of acquired immune deficiency syndromes (1999) · 2016
    Article
  6. Article
  7. Review
  8. Article
  9. Caring for women living with HIV: gaps in the evidence.Journal of the International AIDS Society · 2013
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Howard CrystalDepartment of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. howard.crystal@downstate.edu
Inna Kleyman
Kathryn Anastos
Jason Lazar
Mardge Cohen
Chenglong Liu
Leigh Pearce
Elizabeth Golub
Victor Valcour
Ann Ho
Howard Strickler
Marion Peters
Andrea Kovacs
Susan Holman
Mary Jeanne Kreek
Jennifer Manly
SUNY Downstate Health Sciences University · USGeorgetown University · USJohn H. Stroger, Jr. Hospital of Cook County · USRockefeller University · USAlbert Einstein College of Medicine · USColumbia University Irving Medical Center · USJohns Hopkins University · USMontefiore Medical Center · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
HCV and Progression of HIV and HAART Response in WomenR01AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2002 to 2011
$6.9M
Substance Abuse and HIV: Genetics &Disease ProgressionR01MH076537 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI CRYSTAL, HOWARD A · 2005 to 2009
$2.2M
HIV AND HCV DISEASE PROGRESSION IN WOMEN ON HAARTR56AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2014 to 2014
$655k
NCRR NIH HHS UL1 RR024131NIAID NIH HHS R01 AI052065NIAID NIH HHS R56 AI052065NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS UO1-AI-31834NIAID NIH HHS UO1- AI-34989NIAID NIH HHS UO1-AI-34993NIAID NIH HHS UO1-AI-34994NIAID NIH HHS UO1-AI-35004NIAID NIH HHS UO1-AI-42590NICHD NIH HHS U01 HD032632NICHD NIH HHS UO1-HD-32632NIMH NIH HHS 1R01MH076537-01NIMH NIH HHS R01 MH076537
6 · The paper itself

Abstract

objectiveTo compare neuropsychological scores in women infected with HIV, women infected with both HIV and hepatitis C, and uninfected subjects.

backgroundSome, but not all, studies have demonstrated that dual infection with Hepatitis C virus (HCV) and HIV has worse effects on cognition than infection with HIV alone. DESIGN/

methodsThe Women's Interagency HIV Study is an ongoing prospective study of the natural history of HIV in women where participants are reevaluated every 6 months. In a cross-sectional analysis, we evaluated the effects of active HIV and HCV infections on scores on symbol-digit modalities test, the Stroop interference test, and trails A and B after controlling for age, ethnicity, education, depression, liver disease, and current or past substance abuse.

resultsData were available for 1338 women-17.8 % had detectable hepatitis C virus and 67% were HIV seropositive. In fully adjusted general linear models, HCV viremia was not associated with scores on any of the cognitive tests.

conclusionsIn this large sample of women, active HCV infection was not associated with scores on a small battery of neuropsychological tests.

Indexed as

AdultAgedAnti-HIV AgentsCognition DisordersCohort StudiesCross-Sectional StudiesFemaleHepatitis CHIV InfectionsHumansMiddle AgedMultivariate AnalysisNeuropsychological TestsProspective StudiesRisk FactorsUnited StatesAnti-HIV Agents

Identifiers

PMID22107817
PMCPMC3319079
OpenAlexW1970706561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.