Evidence map›Paper›PMID 22106936›Full record

ArticleOrganic letters2011

Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

Youcai Hu, John B MacMillan

Abstract read
In one paragraph

Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Microorganisms · 2022
    Article
  5. Review
  6. Marine drugs · 2021
    Article
  7. Review
  8. Benzothiazoles from Condensation ofMolecules (Basel, Switzerland) · 2021
    Review
  9. Bacterial terpenome.Natural product reports · 2021
    Review
  10. Article
  11. Article
  12. Genomic-based taxonomic classification of the familyInternational journal of systematic and evolutionary microbiology · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Youcai HuDepartment of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
John B MacMillan
The University of Texas Southwestern Medical Center · US

Funding

Structure guided discovery of small molecule antagonists of Smac (DIABLO)/XIPAP01CA095471 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKNIGHT, STEVEN L · 2002 to 2011
$34.1M
Marine Actinomycetes as a Resource for Anticancer Natural ProductsR01CA149833 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MACMILLAN, JOHN B · 2010 to 2014
$1.6M
NCI NIH HHS P01 CA095471NCI NIH HHS R01 CA149833
6 · The paper itself

Abstract

Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.

Indexed as

Antineoplastic Agents, PhytogenicBenzothiazolesCarcinoma, Non-Small-Cell LungDrug Screening Assays, AntitumorHumansMarine BiologyMolecular StructureSphingomonadaceaeAntineoplastic Agents, PhytogenicBenzothiazoleserythrazole Aerythrazole B

Identifiers

PMID22106936
PMCPMC3237914
OpenAlexW2008502862

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.