Trial reportHypertension (Dallas, Tex. : 1979)2012
Acute β-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes.
Trial report in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Central blood pressure and peripheral augmentation index following acute submaximal arm versus leg exercise.European journal of applied physiology · 2024Article
- Atenolol's Inferior Ability to Reduce Central vs Peripheral Blood Pressure Can Be Explained by the Combination of Its Heart Rate-Dependent and Heart Rate-Independent Effects.International journal of hypertension · 2020Article
- Optimal medical treatment of hypertension in patients with coronary artery disease.Expert review of cardiovascular therapy · 2018Review
- Sex differences in the contribution of blood pressure to acute changes in aortic augmentation index.Journal of human hypertension · 2018Article
- β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.American journal of physiology. Heart and circulatory physiology · 2014Article
- Coronary responses to cold air inhalation following afferent and efferent blockade.American journal of physiology. Heart and circulatory physiology · 2014Article
- Ivabradine therapy to unmask heart rate-independent effects of β-blockers on pulse wave reflections.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.American journal of physiology. Heart and circulatory physiology · 2014Article
- Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults.American journal of hypertension · 2014Article
- Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women.British journal of pharmacology · 2014Review
- Hemodynamic and arterial stiffness differences between African-Americans and Caucasians after maximal exercise.American journal of physiology. Heart and circulatory physiology · 2014Article
- The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women.American journal of hypertension · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Acute β-adrenergic blockade increases aortic wave reflection; however, the mechanisms remain unclear. Evidence suggests that β-adrenergic receptor sensitivity in the peripheral vasculature differs between sexes. Therefore, the goal of this study was to examine whether β-adrenergic blockade alters aortic wave reflection to a similar extent in young men and women. In 31 subjects (16 men and 15 women; 26±1 years) noninvasive aortic pressure waveforms were synthesized from high-fidelity radial pressure waveforms via applanation tonometry before and during systemic β-blockade (0.25 mg/kg bolus, followed by 0.004 mg/kg per minute of continuous infusion of propranolol). β-Blockade increased aortic augmentation index and wave reflection amplitude (aortic augmented pressure) in both sexes (P<0.01). Although the increase in augmentation index was not significantly different between sexes (7.5±1.1% versus 4.6±1.5%; P=0.07), the increase in aortic augmented pressure was greater in women compared with men (2.8±0.5 versus 1.4±0.5 mm Hg; P<0.05). Aortic augmentation index adjusted for a heart rate of 75 bp increased in women (4.1±1.1%; P<0.05) after β-blockade, whereas it was unchanged in men (0.6±1.3%; P=0.33). Moreover, the change in aortic augmentation index was inversely associated with the change in heart rate only in men (r=-0.54; P<0.05). Our data suggest that aortic wave reflection is increased to a greater extent in women after systemic β-blockade, and enhanced aortic wave reflection appears to be mediated by a reduced heart rate in men, whereas the mechanism is unclear in women.
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Registered trials
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