ArticleAntimicrobial agents and chemotherapy2012
In vivo activity of aryl ozonides against Schistosoma species.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Antischistosomal Ozonide Glycine Ethyl Esters.ACS medicinal chemistry letters · 2026Article
- Diversified Synthesis ofACS omega · 2024Article
- Article
- Lewis Acids and Heteropoly Acids in the Synthesis of Organic Peroxides.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis.Molecules (Basel, Switzerland) · 2022Review
- Cyclic Synthetic Peroxides Inhibit Growth of Entomopathogenic FungusMolecules (Basel, Switzerland) · 2020Article
- Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.Journal of medicinal chemistry · 2020Article
- Reassessing therapeutic antibodies for neglected and tropical diseases.PLoS neglected tropical diseases · 2020Review
- Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates.MedChemComm · 2018Article
- Structure⁻Activity Relationship of Piplartine and Synthetic Analogues againstInternational journal of molecular sciences · 2018Article
- Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions.Molecules (Basel, Switzerland) · 2017Review
- Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.International journal for parasitology. Drugs and drug resistance · 2017Article
- Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?Infectious diseases of poverty · 2017Review
- Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.Antimicrobial agents and chemotherapy · 2016Article
- Rearrangements of organic peroxides and related processes.Beilstein journal of organic chemistry · 2016Review
- Repurposing drugs for the treatment and control of helminth infections.International journal for parasitology. Drugs and drug resistance · 2014Review
- Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice.Parasitology research · 2014Article
- Orally active antischistosomal early leads identified from the open access malaria box.PLoS neglected tropical diseases · 2014Article
- In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni.The Journal of antimicrobial chemotherapy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.