ArticleAntimicrobial agents and chemotherapy2012
Seasonal variations in Clostridium difficile infections are associated with influenza and respiratory syncytial virus activity independently of antibiotic prescriptions: a time series analysis in Quebec, Canada.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Clostridium difficile infection seasonality: patterns across hemispheres and continents - a systematic review.PloS one · 2015Pooled it
- Vaccination to Reduce Antimicrobial Resistance Burden-Data Gaps and Future Research.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Maternal vitamin D in pregnancy and infant's gut microbiota: a systematic review.Frontiers in pediatrics · 2023Review
- A Nonlinear Time-Series Analysis to Identify the Thresholds in Relationships Between Antimicrobial Consumption and Resistance in a Chinese Tertiary Hospital.Infectious diseases and therapy · 2022Article
- Candida gut colonization, yeast species distribution, and biofilm production in Clostridioides difficile infected patients: a comparison between three populations in two different time periods.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Potential Roles for Probiotics in the Treatment of COVID-19 Patients and Prevention of Complications Associated with Increased Antibiotic Use.Antibiotics (Basel, Switzerland) · 2021Review
- The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid).Journal of clinical medicine · 2020Article
- Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition andGut microbes · 2020Article
- Long-Term Antibiotic Prophylaxis in Urology and High Incidence ofMicroorganisms · 2020Article
- Effects of Tilmicosin Treatment on the Nasopharyngeal Microbiota of Feedlot Cattle With Respiratory Disease During the First Week of Clinical Recovery.Frontiers in veterinary science · 2020Article
- Seasonality of respiratory viruses and bacterial pathogens.Antimicrobial resistance and infection control · 2019Article
- Temporal association between antibiotic use and resistance inAntimicrobial resistance and infection control · 2018Article
- Temporal relationship between antibiotic use and respiratory virus activities in the Republic of Korea: a time-series analysis.Antimicrobial resistance and infection control · 2018Article
- Genomic Study of aFrontiers in microbiology · 2018Article
- Warmer Weather as a Risk Factor for Cellulitis: A Population-based Investigation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Discontinuation of contact precautions with the introduction of universal daily chlorhexidine bathing.Epidemiology and infection · 2017Article
- Epidemiology ofThe open microbiology journal · 2017Article
- Temporal association between the influenza virus and respiratory syncytial virus (RSV): RSV as a predictor of seasonal influenza.Epidemiology and infection · 2016Article
- Societal Burden and Correlates of Acute Gastroenteritis in Families with Preschool Children.Scientific reports · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seasonal variations in Clostridium difficile-associated diarrhea (CDAD), with a higher incidence occurring during winter months, have been reported. Although winter epidemics of respiratory viruses may be temporally associated with an increase in CDAD morbidity, we hypothesized that this association is mainly due to increased antibiotic use for respiratory infections. The objective of this study was to evaluate the effect of the two most frequent respiratory viruses (influenza virus and respiratory syncytial virus [RSV]) and antibiotics prescribed for respiratory infections (fluoroquinolones and macrolides) on the CDAD incidence in hospitals in the province of Québec, Canada. A multivariable Box-Jenkins transfer function model was built to relate monthly CDAD incidence to the monthly percentage of positive tests for influenza virus and RSV and monthly fluoroquinolone and macrolide prescriptions over a 4-year period (January 2005 to December 2008). Analysis showed that temporal variations in CDAD incidence followed temporal variations for influenza virus (P = 0.043), RSV (P = 0.004), and macrolide prescription (P = 0.05) time series with an average delay of 1 month and fluoroquinolone prescription time series with an average delay of 2 months (P = 0.01). We conclude that influenza virus and RSV circulation is independently associated with CDAD incidence after controlling for fluoroquinolone and macrolide use. This association was observed at an aggregated level and may be indicative of other phenomena occurring during wintertime.
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