ArticleThe Journal of physiology2012
Sound-evoked network calcium transients in mouse auditory cortex in vivo.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
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- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
- Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence.Nature neuroscience · 2021Article
- Brain states govern the spatio-temporal dynamics of resting-state functional connectivity.eLife · 2020Article
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- Multichannel fiber photometry for mapping axonal terminal activity in a restricted brain region in freely moving mice.Neurophotonics · 2019Article
- The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue.Frontiers in neuroscience · 2019Article
- Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology.Frontiers in computational neuroscience · 2019Article
- A corticopontine circuit for initiation of urination.Nature neuroscience · 2018Article
- The Claustrum Supports Resilience to Distraction.Current biology : CB · 2018Article
- Open-source, cost-effective system for low-lightNeurophotonics · 2018Article
- Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves.eLife · 2017Article
- Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Stimulus-specific adaptation in a recurrent network model of primary auditory cortex.PLoS computational biology · 2017Article
- Locomotion-Related Population Cortical CaFrontiers in neural circuits · 2017Article
- Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Knowledge About Sounds-Context-Specific Meaning Differently Activates Cortical Hemispheres, Auditory Cortical Fields, and Layers in House Mice.Frontiers in neuroscience · 2016Article
- Role of Neuromodulation and Optogenetic Manipulation in Pain Treatment.Current neuropharmacology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population calcium signals generated by the action potential activity of local clusters of neurons have been recorded in the auditory cortex of mice using an optical fibre-based approach. These network calcium transients (NCaTs) occurred spontaneously as well as in response to sound stimulation. Two-photon calcium imaging experiments suggest that neurons and neuropil contribute about equally to the NCaT. Sound-evoked calcium signals had two components: an early, fast increase in calcium concentration, which corresponds to the short-latency spiking responses observed in electrophysiological experiments, and a late, slow calcium transient which lasted for at least 1 s. The slow calcium transients evoked by sound were essentially identical to spontaneous NCaTs. Their sizes were dependent on the spontaneous activity level at sound onset, suggesting that spontaneous and sensory-evoked NCaTs excluded each other. When using pure tones as stimulus, the early evoked calcium transients were more narrowly tuned than the slow NCaTs. The slow NCaTs were correlated with global ‘up states' recorded with epidural potentials, and sound presented during an epidural ‘down state' triggered a calcium transient that was associated with an epidural ‘up state'. Essentially indistinguishable calcium transients were evoked by optogenetic activation of local clusters of layer 5 pyramidal neurons in the auditory cortex, indicating that these neurons play an important role in the generation of the calcium signal. Taken together, our results identify sound-evoked slow NCaTs as an integral component of neuronal signalling in the mouse auditory cortex, reflecting the prolonged neuronal activity of local clusters of neurons that can be activated even by brief stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.