Evidence map›Paper›PMID 22106173›Full record

Trial reportThe Journal of physiology2012

Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men.

Nicholas A Burd, Richard J Andrews, Daniel W D West, Jonathan P Little, Andrew J R Cochran, Amy J Hector, Joshua G A Cashaback, Martin J Gibala, James R Potvin, Steven K Baker and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05997095 (Optimisation of Post-operative Electrical Muscle Stimulation), which is not on this map. Cited by 146 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 12 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05997095 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Optimisation of Post-operative Electrical Muscle Stimulation (PoEMS) to Stimulate Muscle Protein Synthesis in Humans

TypeinterventionalSponsorUniversity of NottinghamRan2023 to 2025Enrolled10ConditionsSkeletal Muscle AtrophyArmsNeuromuscular electrical stimulation (NMES/0
3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 12 syntheses or guidelines pooled it, 337 citations in OpenAlex.

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  9. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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  20. The Effects of Eccentric Contraction Execution Time on the Properties of the Patellar Tendon.International journal of environmental research and public health · 2022
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Nicholas A BurdMcMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1.
Richard J Andrews
Daniel W D West
Jonathan P Little
Andrew J R Cochran
Amy J Hector
Joshua G A Cashaback
Martin J Gibala
James R Potvin
Steven K Baker
Stuart M Phillips
McMaster University · CA

Funding

Medical Research Council MR/K00414X/1
6 · The paper itself

Abstract

We aimed to determine if the time that muscle is under loaded tension during low intensity resistance exercise affects the synthesis of specific muscle protein fractions or phosphorylation of anabolic signalling proteins. Eight men (24 ± 1 years (sem), BMI = 26.5 ± 1.0 kg m(-2)) performed three sets of unilateral knee extension exercise at 30% of one-repetition maximum strength involving concentric and eccentric actions that were 6 s in duration to failure (SLOW) or a work-matched bout that consisted of concentric and eccentric actions that were 1 s in duration (CTL). Participants ingested 20 g of whey protein immediately after exercise and again at 24 h recovery. Needle biopsies (vastus lateralis) were obtained while fasted at rest and after 6, 24 and 30 h post-exercise in the fed-state following a primed, constant infusion of l-[ring-(13)C(6)]phenylalanine. Myofibrillar protein synthetic rate was higher in the SLOW condition versus CTL after 24-30 h recovery (P < 0.001) and correlated to p70S6K phosphorylation (r = 0.42, P = 0.02). Exercise-induced rates of mitochondrial and sarcoplasmic protein synthesis were elevated by 114% and 77%, respectively, above rest at 0-6 h post-exercise only in the SLOW condition (both P < 0.05). Mitochondrial protein synthesis rates were elevated above rest during 24-30 h recovery in the SLOW (175%) and CTL (126%) conditions (both P < 0.05). Lastly, muscle PGC-1α expression was increased at 6 h post-exercise compared to rest with no difference between conditions (main effect for time, P < 0.001). These data show that greater muscle time under tension increased the acute amplitude of mitochondrial and sarcoplasmic protein synthesis and also resulted in a robust, but delayed stimulation of myofibrillar protein synthesis 24-30 h after resistance exercise.

Indexed as

Resistance TrainingAmino AcidsBiopsyBlood GlucoseElectromyographyExerciseHumansInsulinMaleMuscle ContractionMuscle ProteinsMuscle, SkeletalTime FactorsYoung AdultAmino AcidsBlood GlucoseInsulinMuscle Proteins

Identifiers

PMID22106173
PMCPMC3285070
OpenAlexW2136662789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.