ArticleThe Journal of physiology2012
Fictive locomotion in the adult decerebrate and spinal mouse in vivo.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Exercise-induced adaptation of neurons in the vertebrate locomotor system.Journal of sport and health science · 2024Review
- Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury.Nature communications · 2024Article
- The Bcm rule allows a spinal cord model to learn rhythmic movements.Biological cybernetics · 2023Article
- Suprapontine Structures Modulate Brainstem and Spinal Networks.Cellular and molecular neurobiology · 2023Article
- Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in theJournal of neurophysiology · 2022Article
- A deep-dive into fictive locomotion - a strategy to probe cellular activity during speed transitions in fictively swimming zebrafish larvae.Biology open · 2022Article
- Article
- Motoneuronal Regulation of Central Pattern Generator and Network Function.Advances in neurobiology · 2022Article
- A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.EMBO molecular medicine · 2020Article
- Biological data questions the support of the self inhibition required for pattern generation in the half center model.PloS one · 2020Article
- Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes.Current opinion in physiology · 2019Article
- Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice.Frontiers in cellular neuroscience · 2019Article
- Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury.The Journal of physiology · 2018Article
- Influence of Brain Stem on Axial and Hindlimb Spinal Locomotor Rhythm Generating Circuits of the Neonatal Mouse.Frontiers in neuroscience · 2018Article
- The neural control of interlimb coordination during mammalian locomotion.Journal of neurophysiology · 2017Review
- Chemogenetic enhancement of functional recovery after a sciatic nerve injury.The European journal of neuroscience · 2017Article
- Decerebrate mouse model for studies of the spinal cord circuits.Nature protocols · 2017Article
- Serotonin controls initiation of locomotion and afferent modulation of coordination via 5-HTThe Journal of physiology · 2017Article
- Speed-Dependent Modulation of the Locomotor Behavior in Adult Mice Reveals Attractor and Transitional Gaits.Frontiers in neuroscience · 2016Article
- Human spinal locomotor control is based on flexibly organized burst generators.Brain : a journal of neurology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, transgenic mice have been created with mutations affecting the components of the mammalian spinal central pattern generator (CPG) for locomotion; however, it has currently only been possible to evoke fictive locomotion in mice, using neonatal in vitro preparations. Here, we demonstrate that it is possible to evoke fictive locomotion in the adult decerebrate mouse in vivo using l-3,4-dihydroxyphenylalanine methyl ester hydrochloride (l-DOPA) and 5-hydroxytryptophan (5HTP) following injection of the monoaminoxiadase inhibitor Nialamide. We investigate the effects of afferent stimulation and spinalization as well as demonstrate the possibility of simultaneous intracellular recording of rhythmically active motoneurones. Our results demonstrate that several features of the mouse locomotor CPG are similar to those that have been observed in rat, cat, rabbit and monkey suggesting a fairly conserved organisation and allowing for future results in transgenic mice to be extrapolated to existing knowledge of CPG components and circuitry obtained in larger species.
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