ArticleJournal of biomedical materials research. Part A2012
Alignment and composition of laminin-polycaprolactone nanofiber blends enhance peripheral nerve regeneration.
Article in Journal of biomedical materials research. Part A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 98 citations in OpenAlex.
- Regenerative medicine approaches for the treatment of peripheral nerve injuries: progress and challenges.Regenerative biomaterials · 2026Review
- Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.Regenerative medicine · 2024Article
- Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications.Biomedicines · 2024Review
- Combining a Density Gradient of Biomacromolecular Nanoparticles with Biological Effectors in an Electrospun Fiber-Based Nerve Guidance Conduit to Promote Peripheral Nerve Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells.Pharmaceutics · 2022Review
- Electrospinning Fabrication Methods to Incorporate Laminin in Polycaprolactone for Kidney Tissue Engineering.Tissue engineering and regenerative medicine · 2022Article
- Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review.Polymers · 2022Article
- Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties.Advanced healthcare materials · 2021Article
- Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration-A Scoping Review.Polymers · 2021Article
- Bioactive Nanofiber-Based Conduits in a Peripheral Nerve Gap Management-An Animal Model Study.International journal of molecular sciences · 2021Article
- Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction.Molecules (Basel, Switzerland) · 2021Review
- 3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine.Materials (Basel, Switzerland) · 2021Article
- Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System.Pharmaceutics · 2021Review
- Neuronal Differentiation from Induced Pluripotent Stem Cell-Derived Neurospheres by the Application of Oxidized Alginate-Gelatin-Laminin Hydrogels.Biomedicines · 2021Article
- A method to rapidly analyze the simultaneous release of multiple pharmaceuticals from electrospun fibers.International journal of pharmaceutics · 2020Article
- RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury.Journal of functional biomaterials · 2019Article
- Exploring the effects of electrospun fiber surface nanotopography on neurite outgrowth and branching in neuron cultures.PloS one · 2019Article
- Combining electrospun nanofibers with cell-encapsulating hydrogel fibers for neural tissue engineering.Journal of biomaterials science. Polymer edition · 2018Article
- The Effect of Laminin Surface Modification of Electrospun Silica Nanofiber Substrate on Neuronal Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2018Article
- Laminin functionalized biomimetic apatite to regulate the adhesion and proliferation behaviors of neural stem cells.International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Peripheral nerve transection occurs commonly in traumatic injury, causing deficits distal to the injury site. Conduits for repair currently on the market are hollow tubes; however, they often fail due to slow regeneration over long gaps. To facilitate increased regeneration speed and functional recovery, the ideal conduit should provide biochemically relevant signals and physical guidance cues, thus playing an active role in regeneration. To that end, laminin and laminin-polycaprolactone (PCL) blend nanofibers were fabricated to mimic peripheral nerve basement membrane. In vitro assays established 10% (wt) laminin content is sufficient to retain neurite-promoting effects of laminin. In addition, modified collector plate design to introduce an insulating gap enabled the fabrication of aligned nanofibers. The effects of laminin content and fiber orientation were evaluated in rat tibial nerve defect model. The lumens of conduits were filled with nanofiber meshes of varying laminin content and alignment to assess changes in motor and sensory recovery. Retrograde nerve conduction speed at 6 weeks was significantly faster in animals receiving aligned nanofiber conduits than in those receiving random nanofiber conduits. Animals receiving nanofiber-filled conduits showed some conduction in both anterograde and retrograde directions, whereas in animals receiving hollow conduits, no impulse conduction was detected. Aligned PCL nanofibers significantly improved motor function; aligned laminin blend nanofibers yielded the best sensory function recovery. In both cases, nanofiber-filled conduits resulted in better functional recovery than hollow conduits. These studies provide a firm foundation for the use of natural-synthetic blend electrospun nanofibers to enhance existing hollow nerve guidance conduits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.