ArticleJournal of biomedical materials research. Part A2012
Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds.
Article in Journal of biomedical materials research. Part A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- 3D bioprinting of fish skin-based gelatin methacryloyl (GelMA) bio-ink for use as a potential skin substitute.Scientific reports · 2024Article
- Biobased polyurethanes for biomedical applications.Bioactive materials · 2021Review
- Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.Advanced healthcare materials · 2016Article
- Substrate modulus of 3D-printed scaffolds regulates the regenerative response in subcutaneous implants through the macrophage phenotype and Wnt signaling.Biomaterials · 2015Article
- A transient cell-shielding method for viable MSC delivery within hydrophobic scaffolds polymerized in situ.Biomaterials · 2015Article
- Article
- A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species.Biomaterials · 2014Article
- Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Biodegradable lysine-derived polyurethane scaffolds promote healing in a porcine full-thickness excisional wound model.Journal of biomaterials science. Polymer edition · 2014Article
- Strategies Demonstrating Efficacy in Reducing Wound ContractionAdvances in wound care · 2013Review
- Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films.Acta biomaterialia · 2013Article
- Sustained local delivery of siRNA from an injectable scaffold.Biomaterials · 2012Article
- Injectable foams for regenerative medicine.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Injectable scaffolds present compelling opportunities for wound repair and regeneration because of their ability to fill irregularly shaped defects and deliver biologics such as growth factors. In this study, we investigated the properties of injectable polyurethane (PUR) biocomposite scaffolds and their application in cutaneous wound repair using a rat excisional model. The scaffolds have a minimal reaction exotherm and clinically relevant working and setting times. Moreover, the biocomposites have mechanical and thermal properties consistent with rubbery elastomers. In the rat excisional wound model, injection of settable biocomposite scaffolds stented the wounds at early time points, resulting in a regenerative rather than a scarring phenotype at later time points. Measurements of wound length and thickness revealed that the treated wounds were less contracted at day 7 compared to blank wounds. Analysis of cell proliferation and apoptosis showed that the scaffolds were biocompatible and supported tissue ingrowth. Myofibroblast formation and collagen fiber organization provided evidence that the scaffolds have a positive effect on extracellular matrix remodeling by disrupting the formation of an aligned matrix under elevated tension. In summary, we have developed an injectable biodegradable PUR biocomposite scaffold that enhances cutaneous wound healing in a rat model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.