ArticleAmerican journal of ophthalmology2012
Outer retinal structure in patients with acute zonal occult outer retinopathy.
Article in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex.PloS one · 2014Trial
- Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8.Eye (London, England) · 2025Observational
- Extracting spacing-derived estimates of rod density in healthy retinae.Biomedical optics express · 2023Article
- Determination of Length of Interdigitation Zone by Optical Coherence Tomography and Retinal Sensitivity by Microperimetry and Their Relationship to Progression of Retinitis Pigmentosa.BioMed research international · 2019Article
- Peripheral Cone Dystrophy: Expanded Clinical Spectrum, Multimodal and Ultrawide-Field Imaging, and Genomic Analysis.Journal of ophthalmology · 2018Article
- Quantitative Autofluorescence Intensities in Acute Zonal Occult Outer Retinopathy vs Healthy Eyes.JAMA ophthalmology · 2017Article
- Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.Investigative ophthalmology & visual science · 2017Review
- Article
- Evaluating Descriptive Metrics of the Human Cone Mosaic.Investigative ophthalmology & visual science · 2016Article
- Parafoveal cone abnormalities and recovery on adaptive optics in posterior uveitis.American journal of ophthalmology case reports · 2016Article
- Assessment of Different Sampling Methods for Measuring and Representing Macular Cone Density Using Flood-Illuminated Adaptive Optics.Investigative ophthalmology & visual science · 2015Article
- Spontaneous remission of acute zonal occult outer retinopathy: follow-up using adaptive optics scanning laser ophthalmoscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Chapter 6 - Restoring Vision to the Blind: Neuroprotection.Translational vision science & technology · 2014Article
- Outer retinal structure after closed-globe blunt ocular trauma.Retina (Philadelphia, Pa.) · 2014Article
- Optical coherence tomography imaging in uveitis.International ophthalmology · 2014Review
- Two types of acute zonal occult outer retinopathy differentiated by dark- and light-adapted perimetry.Japanese journal of ophthalmology · 2014Article
- Selective cone photoreceptor injury in acute macular neuroretinopathy.Retina (Philadelphia, Pa.) · 2013Article
- Accuracy of the Heidelberg Spectralis in the alignment between near-infrared image and tomographic scan in a model eye: a multicenter study.American journal of ophthalmology · 2013Article
- Adaptive optics retinal imaging--clinical opportunities and challenges.Current eye research · 2013Review
- Changes in optical coherence tomography findings in acute zonal occult outer retinopathy.Case reports in ophthalmology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo correlate visual function with high-resolution images of retinal structure using adaptive optics scanning laser ophthalmoscopy (AOSLO) in 4 patients with acute zonal occult outer retinopathy (AZOOR).
designObservational case series.
methodsFour women, aged 18 to 51, with acute focal loss of visual field or visual acuity, photopsia, and minimal funduscopic changes were studied with best-corrected visual acuity (BCVA), Goldmann kinetic and automated perimetry and fundus-guided microperimetry, full-field and multifocal electroretinography (ffERG and mfERG), spectral-domain optical coherence tomography (SD-OCT), and AOSLO imaging. Cone spacing was measured in 4 eyes and compared with 27 age-similar normal eyes. Additional functional testing in 1 patient suggested that cones were absent but rods remained. Serum from all patients was analyzed for anti-retinal antibody activity.
resultsIn all patients vision loss was initially progressive, then stable. Symptoms were unilateral in 2 and bilateral but asymmetric in 2 patients. In each patient, loss of retinal function correlated with structural changes in the outer retina. AOSLO showed focal cone loss in most patients, although in 1 patient with central vision loss such change was absent. In another patient, structural and functional analyses suggested that cones had degenerated but rods remained. Anti-retinal antibody activity against a ∼45 kd antigen was detected in 1 of the patients; the other 3 patients showed no evidence of abnormal anti-retinal antibodies.
conclusionsFocal abnormalities of retinal structure correlated with vision loss in patients with AZOOR. High-resolution imaging can localize and demonstrate the extent of outer retinal abnormality in AZOOR patients.
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Registered trials
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