SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis.Zeitschrift fur Rheumatologie · 2017Pooled it
- CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.Molecular biology reports · 2013Pooled it
- The role of the endothelial nitric oxide synthase variants in the development of juvenile idiopathic arthritis and its clinical findings.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Review
- The rs3918188 and rs1799983 loci of eNOS gene are associated with susceptibility in patients with systemic lupus erythematosus in Northeast China.Scientific reports · 2024Article
- Association of a NOS3 gene polymorphism with Behçet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese.Molecular vision · 2016Article
- Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?Clinics (Sao Paulo, Brazil) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE).
methodsA meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and lupus nephritis (LN) (when available) using (1) the allele contrast, (2) the recessive, (3) the dominant, and (4) the additive models.
resultsA total of eight studies, which included 1,297 cases and 1,214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in any study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphism and LN in SLE patients [odds ratio (OR) = 2.125, 95% confidence interval (CI) = 1.289-3.054, p = 0.003; OR = 2.655, 95% CI = 1.509-4.671, p = 0.001]. No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency to an association between the TT genotype and SLE (OR = 1.220, 95% CI = 1.000-1.489, p = 0.050), and meta-analysis of the TT versus CC genotype of the C786T polymorphism in group in Hardy-Weinberg equilibrium revealed a significant association between the TT genotype and SLE (OR = 1.643, 95% CI = 1.021-2.644, p = 0.041).
conclusionsThis meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.