ArticleMolecular psychiatry2012
Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence.
Article in Molecular psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.Alcoholism, clinical and experimental research · 2022Pooled it
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry When Biology Could Be Associated With Both Symptoms and Syndromes.Biological psychiatry · 2026Review
- Genetic risk for alcohol use disorder in relation to individual symptom criteria: Do polygenic indices provide unique information for understanding severity and heterogeneity?Addiction (Abingdon, England) · 2025Article
- Factors that increase risk for alcohol-induced blackouts in high-intensity drinking young adults.Alcohol, clinical & experimental research · 2025Article
- "General Addiction Liability" Revisited.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Examination of the mild, moderate, and severe alcohol use disorder severity indicators using a nationally representative sample.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Article
- Disentangling differing relationships between internalizing disorders and alcohol use.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA).Molecular and cellular neurosciences · 2023Article
- New approaches to deep phenotyping in addictions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Review
- Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task.Human brain mapping · 2023Article
- Contextual decision-making and alcohol use disorder criteria: Delayed reward, delayed loss, and probabilistic reward discounting.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- An exploration of multivariate symptom clusters of cannabis use disorder in young adults.Addictive behaviors · 2022Article
- Is lower severity alcohol use disorder qualitatively different than more severe manifestations? An evaluation of multivariate symptom clusters.Addiction (Abingdon, England) · 2022Article
- Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.Alcoholism, clinical and experimental research · 2022Article
- Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Does crude measurement contribute to observed unidimensionality of psychological constructs? A demonstration with DSM-5 alcohol use disorder.Journal of abnormal psychology · 2021Article
- Genetic and Pharmacological Manipulations of Glyoxalase 1 Mediate Ethanol Withdrawal Seizure Susceptibility in Mice.Brain sciences · 2021Article
- Risk and resilience for alcohol use disorder revealed in brain functional connectivity.NeuroImage. Clinical · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To determine the number of genetic factors underlying the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for alcohol dependence (AD), we conducted structural equation twin modeling for seven AD criteria, plus two summary screening questions, in 7133 personally interviewed male and female twins from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, who reported lifetime alcohol consumption. The best-fit twin model required three genetic and two unique environmental common factors, and criterion-specific unique environmental factors. The first genetic factor was defined by high loadings for the probe question about quantity and frequency of alcohol consumption, and tolerance criterion. The second genetic factor loaded strongly on the probe question about self-recognition of alcohol-related problems and AD criteria for loss of control, desire to quit, preoccupation and activities given up. The third genetic factor had high loadings for withdrawal and continued use despite the problems criteria. Genetic factor scores derived from these three factors differentially predicted patterns of comorbidity, educational status and other historical/clinical features of AD. The DSM-IV syndrome of AD does not reflect a single dimension of genetic liability, rather, these criteria reflect three underlying dimensions that index risk for: (i) tolerance and heavy use; (ii) loss of control with alcohol associated social dysfunction and (iii) withdrawal and continued use despite problems. While tentative and in need of replication, these results, consistent with the rodent literature, were validated by examining predictions of the genetic factor scores and have implications for gene-finding efforts in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.