ArticlePediatric cardiology2012
Assessment of risk factors for Korean children with Kawasaki disease.
Article in Pediatric cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis.European journal of pediatrics · 2013Pooled it
- Establishment and validation of a nomogram for predicting intravenous immunoglobulin resistance and coronary artery lesion involvement in Kawasaki disease: a retrospective study.Clinical rheumatology · 2025Article
- Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
- Article
- Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features.Medicina (Kaunas, Lithuania) · 2022Review
- Clinical implications of thrombocytosis in acute phase Kawasaki disease.European journal of pediatrics · 2021Article
- Epidemiologic Features of Kawasaki Disease in Shanghai From 2013 Through 2017.Journal of epidemiology · 2020Article
- Clinical manifestations of Kawasaki disease in different age groups: retrospective data from Southwest China.Clinical rheumatology · 2020Article
- Neutrophil-to-lymphocyte ratio and scoring system for predicting coronary artery lesions of Kawasaki disease.BMC pediatrics · 2020Article
- Immunogenetics of Kawasaki disease.Clinical reviews in allergy & immunology · 2020Review
- Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2020Review
- Association between maternal age and outcomes in Kawasaki disease patients.Pediatric rheumatology online journal · 2019Article
- Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease.Korean journal of pediatrics · 2019Article
- A new scoring system to predict Kawasaki disease with coronary artery lesions.Clinical rheumatology · 2019Article
- Neutrophil-to-Lymphocyte Ratio Predicts Intravenous Immunoglobulin-Resistance in Infants Under 12-Months Old With Kawasaki Disease.Frontiers in pediatrics · 2019Article
- ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population.Disease markers · 2018Article
- Changes in clinical and laboratory features of Kawasaki disease noted over time in Daejeon, Korea.Pediatric rheumatology online journal · 2017Article
- Cardiac involvement in primary systemic vasculitis and potential drug therapies to reduce cardiovascular risk.Rheumatology international · 2017Review
- Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease.PloS one · 2017Article
- Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study.Korean circulation journal · 2016Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% of KD patients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/AC genotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serum albumin concentration is an independent risk factor for IVIG nonresponsiveness.
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