Trial reportObstetrics and gynecology2011
Optical coherence tomography compared with colposcopy for assessment of vaginal epithelial damage: a randomized controlled trial.
Trial report in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- An intravaginal ring for HIV pre-exposure prophylaxis: assessment of safety and pharmacokinetics in a randomized, placebo-controlled clinical trial.Frontiers in cellular and infection microbiology · 2026Trial
- Visualization of synthetic mesh utilizing optical coherence tomography.International urogynecology journal · 2013Trial
- Depth-Resolved Attenuation Mapping of the Vaginal Wall under Prolapse and after Laser Treatment Using Cross-Polarization Optical Coherence Tomography: A Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Optical coherence tomography evaluation of vaginal epithelial thickness during COJournal of biophotonics · 2022Article
- Surrogate post-coital testing for contraceptive efficacy against human sperm activity in the ovine vaginal model†.Biology of reproduction · 2021Article
- High-Resolution Quantitative Mapping of Macaque Cervicovaginal Epithelial Thickness: Implications for Mucosal Vaccine Delivery.Frontiers in immunology · 2021Article
- Optical Vaginal Biopsy Using Optical Coherence Tomography.Female pelvic medicine & reconstructive surgery · 2020Article
- Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.Frontiers in cellular and infection microbiology · 2020Article
- Endometrium imaging using real-time rotational optical coherence tomography imaging system: A pilot, prospective and ex-vivo study.Medicine · 2019Observational
- A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- 1.7 micron optical coherence tomography for vaginal tissue characterization in vivo.Lasers in surgery and medicine · 2019Article
- Colposcopic imaging using visible-light optical coherence tomography.Journal of biomedical optics · 2017Article
- Topical injury evaluation of the murine colorectal mucosa using confocal endomicrosopy: a valuable method for assessing mucosal injuries associated with risk of pathogen transmission.Journal of microscopy · 2016Article
- Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides.Sexually transmitted diseases · 2013Article
- Monitoring vaginal epithelial thickness changes noninvasively in sheep using optical coherence tomography.American journal of obstetrics and gynecology · 2013Article
- Optical coherence tomography for assessment of microbicide safety in a small animal model.Journal of biomedical optics · 2013Article
- Automated segmentation algorithm for detection of changes in vaginal epithelial morphology using optical coherence tomography.Journal of biomedical optics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveColposcopy has been used to detect epithelial damage with vaginal microbicides. In animal models, optical coherence tomography provided increased sensitivity over colposcopy in detecting epithelial injury. This randomized, double-blinded, clinical study compared optical coherence tomography to colposcopy for the evaluation of epithelial injury in women using placebo or nonoxynol-9.
methodsThirty women aged 18-45 were randomized to use hydroxyethyl cellulose placebo or nonoxynol-9 vaginal gel twice daily for 5.5 days. Imaging with colposcopy and optical coherence tomography was performed before product use, after the last dose, and 1 week later. Colposcopy was graded using standard criteria. Optical coherence tomography images were scored for epithelial integrity based on a published scoring system and were measured for epithelial thickness.
resultsColposcopy findings, optical coherence tomography scores, and epithelial thicknesses were similar between treatment groups at baseline. After treatment, there were significant differences between the nonoxynol-9 (1.37) and control group (1.15) optical coherence tomography scores (P<.001), indicating epithelial injury, and there was epithelial thinning in the nonoxynol-9 group (237 micrometers) compared with the control group (292 micrometers; P=.008). There were no significant posttreatment colposcopic differences in epithelial disruption between treatment groups, with only increased erythema noted after nonoxynol-9 use (P=.02).
conclusionOptical coherence tomography detected epithelial disruption and thinning not identified by colposcopy. Vaginal epithelial thickness, a measure previously available only through biopsy, decreased after nonoxynol-9 use, a finding that may contribute to increased susceptibility to human immunodeficiency virus after frequent use. Optical coherence tomography shows promise for the noninvasive clinical assessment of vaginal epithelial damage. CLINICAL
trial registrationUMIN Clinical Trials Registry, www.umin.ac.jp/ctr/index.htm, R000006186. LEVEL OF EVIDENCE: I.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.