ReviewNature reviews. Rheumatology2011
Hand osteoarthritis--a heterogeneous disorder.
Review in Nature reviews. Rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 216 citations in OpenAlex.
- A systematic review of the association between ultrasound-detected features and laboratory inflammatory biomarkers in hand osteoarthritis.Annals of medicine · 2025Pooled it
- The prognosis of pain and function in people with hand and thumb base osteoarthritis: a systematic review.Annals of medicine · 2025Pooled it
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Surgical denervation as a treatment strategy for pain in hand osteoarthritis: a systematic literature review.RMD open · 2023Pooled it
- Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.Annals of the rheumatic diseases · 2023Pooled it
- Intra-Articular Therapies in the Treatment of Hand Osteoarthritis: A Systematic Literature Review.Drugs & aging · 2016Pooled it
- Trial
- Effect of heated mittens on physical hand function in people with hand osteoarthritis: randomised controlled trial.BMJ (Clinical research ed.) · 2024Trial
- Neuropathic-like pain symptoms in inflammatory hand osteoarthritis lower quality of life and may not decrease under prednisolone treatment.European journal of pain (London, England) · 2022Trial
- Initial stages of hand osteoarthritis do not affect the extrinsic muscles of the hand: a cross-sectional study.Scientific reports · 2021Trial
- Observational
- Three-Dimensional Motion Analysis of Finger in Sport Climbing in Different Age Groups.Bioengineering (Basel, Switzerland) · 2026Article
- Oral microbiome dysbiosis and oral-gut microbial network disruption in hand osteoarthritis: data from the Xiangya Osteoarthritis Study.RMD open · 2026Observational
- Methotrexate for hand osteoarthritis.The Cochrane database of systematic reviews · 2026Article
- Evaluation of the use of segmentation-based and deconvolution-based three-dimensional joint space width analysis of the hand and wrist.JBMR plus · 2026Article
- Automated ultrasound with AI for osteophyte grading in hand osteoarthritis: comparison with expert rheumatologist assessment.BMC rheumatology · 2026Article
- PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis.The Journal of biological chemistry · 2026Article
- Factors associated with radiographic progression of hand osteoarthritis over 2 years.RMD open · 2026Article
- The stability of pain phenotypes in people with hand osteoarthritis - results from the NOR-HAND study.Osteoarthritis and cartilage open · 2026Article
- Ultrasound-detected synovitis in symptomatic hand osteoarthritis is associated with functional impairment: data from the LIHOA cohort.Advances in rheumatology (London, England) · 2026Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand osteoarthritis (OA) is a prevalent disorder. Hand OA is not one single disease, but a heterogeneous group of disorders. Radiographic signs of hand OA, such as osteophytes or joint space narrowing, can be found in up to 81% of the elderly population. Several hand OA subsets--such as nodal interphalangeal OA, thumb base OA and erosive OA--can be discriminated. Furthermore, the experience of symptoms and the course of the disease differ between patients. Studies that used well-defined study populations with longitudinal follow-up have shown that similarities and differences can be observed in the pathogenesis, epidemiology and risk factors of the various hand OA subsets. Erosive OA in particular, characterized by erosive lesions on radiographical images, has a higher clinical burden and worse outcome than nonerosive hand OA. Imaging modalities (such as ultrasonography) have increased our knowledge of the role of inflammation of the disease. Our understanding of the heterogeneous nature of hand OA can eventually lead to increased knowledge of the pathogenesis of, and ultimately new treatment modalities for, this complex disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.