ReviewNature reviews. Neurology2011
Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies.
Review in Nature reviews. Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- The diagnostic value of quantitative assessment of MR neurography in chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and meta-analysis.The British journal of radiology · 2023Pooled it
- Incidence and Prevalence of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis.Neuroepidemiology · 2019Pooled it
- Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy.Journal of neurology · 2019Trial
- Intravenous immunoglobulin frequency in multifocal motor neuropathy: a retrospective study of nerve conduction outcomes.BMC neurology · 2026Article
- Clinical and electrophysiological features for differentiating MMN from hand-onset ALS.Journal of the Chinese Medical Association : JCMA · 2026Article
- Atypical Multifocal Motor Neuropathy Presenting With Isolated Spinal Accessory and Pectoral Nerve Involvement.Cureus · 2026Article
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches.Brain and behavior · 2026Review
- Raw, centile and individualised minimal clinically important differences for the MMN-Rasch-built Overall Disability ScaleJournal of neurology · 2026Article
- Blood-Nerve Barrier Breakdown Induced by Immunoglobulin G in Typical and Multifocal Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy.International journal of molecular sciences · 2026Article
- IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Epidemiology, Patient Characteristics, Real-World Treatment Patterns, and Healthcare Utilization and Spending for Patients with Multifocal Motor Neuropathy: A US Claims-Based Analysis.Journal of health economics and outcomes research · 2026Article
- Long-Term Functional Outcomes in Immunoglobulin-Treated Multifocal Motor Neuropathy Evaluated Through the MMN-Rasch-Built Overall Disability Scale.Journal of the peripheral nervous system : JPNS · 2025Article
- Variably Defined Conduction Block, Temporal Dispersion and Other Electrophysiological Abnormalities in Multifocal Motor Neuropathy: A Multicentre Study.European journal of neurology · 2025Article
- Nerve Conduction Abnormalities Beyond Conduction Block in Multifocal Motor Neuropathy. Impact on Diagnostic Criteria Accuracy.European journal of neurology · 2025Article
- Diagnosis and Management of Multifocal Motor Neuropathy in the United Kingdom: A Multicentre Survey.Journal of the peripheral nervous system : JPNS · 2025Article
- Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies.Journal of the peripheral nervous system : JPNS · 2025Article
- Complement activation by IgM autoantibodies linked to immune-mediated neuropathies depends on C2.European journal of neurology · 2025Article
- Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy.European journal of neurology · 2024Article
- Prevention of axonal loss after immediate dosage titration of immunoglobulin in multifocal motor neuropathy.European journal of neurology · 2024Article
- Assessment of diagnostic criteria for multifocal motor neuropathy in patients included in the Italian database.European journal of neurology · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy characterized by slowly progressive, asymmetric distal limb weakness without sensory loss. The clinical presentation of MMN may mimic amyotrophic lateral sclerosis, other variants of motor neuron disease, or chronic inflammatory demyelinating polyneuropathy with asymmetric onset. Differentiation is important, as these diseases differ in prognosis and treatment. The electrophysiological finding of conduction block in the absence of abnormalities in sensory nerves is the hallmark of MMN, but can be difficult to detect. Intravenous immunoglobulin is efficacious in most patients, but long-term maintenance therapy does not prevent slowly progressive axonal degeneration. Moreover, cyclophosphamide, although effective, has substantial adverse effects, and the efficacy of other immunosuppressive drugs, including rituximab, is not established. The underlying pathological mechanisms of MMN are unclear, but IgM autoantibodies against the ganglioside GM1 may cause changes in nodal and perinodal structures that compromise nerve conduction. Further elucidation of the disease mechanisms may ultimately lead to improved treatment strategies. In this Review, we discuss the diagnostic criteria for MMN, and provide an update on the current understanding of MMN pathogenesis. We also describe available treatments and promising new therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.