Evidence map›Paper›PMID 22105176›Full record

ArticleThe Journal of clinical investigation2011

Slowing down with age: lung DCs do it too.

Thomas J Braciale, Taeg S Kim

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Thomas J BracialeBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA. tjb2r@virginia.edu
Taeg S Kim

Funding

Regulation of CD8+ T cell responses via liver NK-DC crosstalkU19AI083024 · NIAID · UNIVERSITY OF VIRGINIA · PI BRACIALE, THOMAS J · 2009 to 2013
$8.1M
CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUSR01AI015608 · NIAID · WASHINGTON UNIVERSITY · PI BRACIALE, THOMAS J · 1985 to 2017
$5.7M
T Cell Function in Pulmonary Viral Pulmonary Infection and InjuryR01HL033391 · NHLBI · WASHINGTON UNIVERSITY · PI BRACIALE, THOMAS J · 1985 to 2012
$4.3M
IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTIONR01AI037293 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BRACIALE, THOMAS J · 1994 to 2007
$2.3M
NHLBI NIH HHS R01 HL033391NHLBI NIH HHS R01 HL-33391NIAID NIH HHS R01 AI015608NIAID NIH HHS R01 AI037293NIAID NIH HHS R01 AI-15608NIAID NIH HHS R01 AI-37293NIAID NIH HHS U19 AI083024NIAID NIH HHS U-19 AI-83024
6 · The paper itself

Abstract

Decline in immune function with age has been attributed to defects or alterations in both the innate and the adaptive immune system. In this issue of the JCI, Zhao and coworkers provide evidence for a novel mechanism of immune dysfunction in aging mice. They show that migration of respiratory DCs from the site of virus replication to the draining lymph nodes in response to infection with several different respiratory viruses is markedly diminished with increasing age. The impaired DC migration was a result of increased levels of the lipid mediator prostaglandin D(2) (PGD(2)) in the respiratory tract with age and could be partially reversed by blockade of PGD(2) synthesis or action.

Indexed as

AgingAnimalsCoronavirus InfectionsDendritic CellsOrthomyxoviridae InfectionsProstaglandin D2Respiratory Syncytial Virus InfectionsT-Lymphocyte SubsetsProstaglandin D2

Identifiers

PMID22105176
PMCPMC3226069

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.