ArticleThe Journal of clinical investigation2011
On the origin of the liver.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Review
- Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening.International journal of molecular sciences · 2021Review
- Collapse of the hepatic gene regulatory network in the absence of FoxA factors.Genes & development · 2020Article
- Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways.Experimental & molecular medicine · 2017Article
- Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.The Journal of clinical investigation · 2015Article
- Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.The EMBO journal · 2015Article
- Tissue Remodelling following Resection of Porcine Liver.BioMed research international · 2015Article
- Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.Cell stem cell · 2014Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
While it has been well established that the fetal liver originates from foregut endoderm, the identity of the mechanisms that maintain liver mass under both basal and injury conditions remains controversial. Dramatically different models have been proposed based on the experimental design employed. In this issue of the JCI, Malato and colleagues report their elegant new model for genetic lineage tracing of mature mouse hepatocytes using an adenoassociated virus-driven Cre recombinase. They show convincingly that maintenance of liver mass during normal turnover or in response to mild injury is achieved by mature hepatocytes, rather than cholangiocytes or specialized progenitor cells, as has been suggested by others.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.