ArticleInvestigative radiology2012
Quantitative mapping of tumor vascularity using volumetric contrast-enhanced ultrasound.
Article in Investigative radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 87 citations in OpenAlex.
- Ultrasound imaging of breast tumor perfusion and neovascular morphology.Ultrasound in medicine & biology · 2015Trial
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Motion correction of 3D dynamic contrast-enhanced ultrasound imaging without anatomical B-Mode images: Pilot evaluation in eight patients.Medical physics · 2024Article
- Vascular phenotyping of the invasive front in breast cancer using a 3D angiogenesis atlas.Microvascular research · 2023Article
- Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle.Nature communications · 2023Article
- Assessment of Transarterial Chemoembolization Using Super-resolution Ultrasound Imaging and a Rat Model of Hepatocellular Carcinoma.Ultrasound in medicine & biology · 2023Article
- 3-D Super-Resolution Ultrasound Imaging for Monitoring Early Changes in Breast Cancer after Treatment with a Vascular-Disrupting Agent.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2021Article
- Early prediction of response to neoadjuvant chemotherapy using contrast-enhanced ultrasound in breast cancer.Medicine · 2021Observational
- Three-dimensional visualization and improved quantification with super-resolution ultrasound imaging - validation framework for analysis of microvascular morphology using a chicken embryo model.Physics in medicine and biology · 2021Article
- Tumor Vascular Networks Depicted in Contrast-Enhanced Ultrasound Images as a Predictor for Transarterial Chemoembolization Treatment Response.Ultrasound in medicine & biology · 2020Article
- Three-dimensional evaluation of microvascular networks using contrast-enhanced ultrasound and microbubble tracking.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020Article
- Faster motion correction of clinical contrast-enhanced ultrasound imaging using deep learning.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020Article
- Multiscale and morphological analysis of microvascular patterns depicted in contrast-enhanced ultrasound images.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Contrast-enhanced ultrasound imaging of acute changes in pancreatic cancer following targeted hyaluronan treatment.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2019Article
- Multiscale quantification of tumor microarchitecture for predicting therapy response using dynamic contrast-enhanced ultrasound imaging.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2019Article
- Impact of hydrostatic pressure on phase-change contrast agent activation by pulsed ultrasound.The Journal of the Acoustical Society of America · 2019Article
- Plane wave versus focused transmissions for contrast enhanced ultrasound imaging: the role of parameter settings and the effects of flow rate on contrast measurements.Physics in medicine and biology · 2019Article
- Improved quantitative contrast-enhanced ultrasound imaging of hepatocellular carcinoma response to transarterial chemoembolization.Proceedings. IEEE International Symposium on Biomedical Imaging · 2019Article
- Morphological image processing for multiscale analysis of super-resolution ultrasound images of tissue microvascular networks.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.The Journal of clinical investigation · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe goal of this research project was to develop a volumetric strategy for real-time monitoring and characterization of tumor blood flow using microbubble contrast agents and ultrasound (US) imaging. MATERIALS AND
methodsVolumetric contrast-enhanced US (VCEUS) imaging was implemented on a SONIX RP US system (Ultrasonix Medical Corp, Richmond, BC) equipped with a broadband 4DL14-5/38 probe. Using a microbubble-sensitive harmonic imaging mode (transducer transmits at 5 MHz and receives at 10 MHz), acquisition of postscan-converted VCEUS data was achieved at a volume rate of 1 Hz. After microbubble infusion, custom data processing software was used to derive microbubble time-intensity curve-specific parameters, namely, blood volume (IPK), transit time (T1/2PK), flow rate (SPK), and tumor perfusion (AUC).
resultsUsing a preclinical breast cancer animal model, it is shown that millimeter-sized deviations in transducer positioning can have profound implications on US-based blood flow estimators, with errors ranging from 6.4% to 40.3% and dependent on both degree of misalignment (offset) and particular blood flow estimator. These errors indicate that VCEUS imaging should be considered in tumor analyses, because they incorporate the entire mass and not just a representative planar cross-section. After administration of an antiangiogenic therapeutic drug (bevacizumab), tumor growth was significantly retarded compared with control tumors (P > 0.03) and reflects observed changes in VCEUS-based blood flow measurements. Analysis of immunohistologic data revealed no differences in intratumoral necrosis levels (P = 0.70), but a significant difference was found when comparing microvessel density counts in control with therapy group tumors (P = 0.05).
conclusionsVCEUS imaging was shown to be a promising modality for monitoring changes in tumor blood flow. Preliminary experimental results are encouraging, and this imaging modality may prove clinically feasible for detecting and monitoring the early antitumor effects in response to cancer drug therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.