ReviewCritical care (London, England)2011
Bench-to-beside review: acute-on-chronic liver failure - linking the gut, liver and systemic circulation.
Review in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Interaction of inflammation and portal hypertension in cirrhosis progression.Nature reviews. Gastroenterology & hepatology · 2025Review
- The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure.Frontiers in microbiology · 2025Review
- Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases.Frontiers in nutrition · 2025Review
- Pathogenesis and clinical features of severe hepatitis E virus infection.World journal of virology · 2024Review
- Temperature Responsive Polymer Conjugate Prepared by "Grafting from" Proteins toward the Adsorption and Removal of Uremic Toxin.Molecules (Basel, Switzerland) · 2022Article
- Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure.Frontiers in cellular and infection microbiology · 2021Article
- Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice.Scientific reports · 2020Article
- Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury.Frontiers in immunology · 2020Article
- Novel use of Cytosorb™ haemadsorption to provide biochemical control in liver impairment.Journal of the Intensive Care Society · 2019Article
- Disruption of the gut-liver axis in the pathogenesis of acute-on-chronic liver failure.European journal of gastroenterology & hepatology · 2018Review
- Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough.Canadian journal of gastroenterology & hepatology · 2018Review
- FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.Scientific reports · 2016Article
- Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management.World journal of gastroenterology · 2015Review
- Clinical profile, natural history, and predictors of mortality in patients with acute-on-chronic liver failure (ACLF).Wiener klinische Wochenschrift · 2015Observational
- Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation.World journal of gastroenterology · 2014Article
- Severe alcoholic hepatitis-current concepts, diagnosis and treatment options.World journal of hepatology · 2014Review
- Understanding infection susceptibility in patients with acute-on-chronic liver failure.Intensive care medicine · 2014Review
- Hepatitis E and Acute-on-Chronic Liver Failure.Journal of clinical and experimental hepatology · 2013Review
- Liver: How can acute-on-chronic liver failure be accurately identified?Nature reviews. Gastroenterology & hepatology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of acute-on-chronic liver failure (ACLF) was introduced recently to describe a subset of patients with chronic liver disease presenting with profound deterioration of liver function and rapidly evolving multi-organ failure. ACLF is frequently accompanied by the development of severe inflammatory response syndrome and has a high mortality. To date, treatment options are limited and exclusively supportive. Over the last few years, some insights have been generated in the pathophysiology of ACLF. A key role for the interaction of innate immune dysfunction, enhanced bacterial translocation from the gut, and circulatory dysfunction has been proposed. In this respect, therapeutic strategies have been examined, with variable success, in experimental studies in animals and humans. This review focuses on potentially relevant pathophysiological elements in the development of ACLF and points out promising treatment modalities in ACLF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.