Trial reportThe Journal of allergy and clinical immunology2012
Adherence to inhaled corticosteroids: an ancillary study of the Childhood Asthma Management Program clinical trial.
Trial report in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Systematic Review of Digital Interventions for Pediatric Asthma Management.The journal of allergy and clinical immunology. In practice · 2020Pooled it
- A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans.The journal of allergy and clinical immunology. In practice · 2019Pooled it
- Interventions to improve adherence to inhaled steroids for asthma.The Cochrane database of systematic reviews · 2017Pooled it
- Improving Adherence in Urban Youth With Asthma: Role of Community Health Workers.The journal of allergy and clinical immunology. In practice · 2022Trial
- A data-driven typology of asthma medication adherence using cluster analysis.Scientific reports · 2020Trial
- School-supervised use of a once-daily inhaled corticosteroid regimen: A cluster randomized trial.The Journal of allergy and clinical immunology · 2019Trial
- Individualized therapy for persistent asthma in young children.The Journal of allergy and clinical immunology · 2016Trial
- Feasibility, acceptability and preliminary effectiveness of patient advocates for improving asthma outcomes in adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2013Trial
- The association of health literacy with adherence and outcomes in moderate-severe asthma.The Journal of allergy and clinical immunology · 2013Trial
- The impact of peer support and mp3 messaging on adherence to inhaled corticosteroids in minority adolescents with asthma: a randomized, controlled trial.The journal of allergy and clinical immunology. In practiceTrial
- What Really Happens in the Home: The Medication Environment of Urban, Minority Youth.The journal of allergy and clinical immunology. In practiceTrial
- Follow-up study on factors influencing the persistence of asthma in discharged children.BMC pediatrics · 2026Article
- High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry.Pediatric nephrology (Berlin, Germany) · 2026Article
- Multilevel facilitators of pediatric asthma outcomes: The role of caregiver self-efficacy.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- An Overview of Adherence-What It Is and Why It Is Important.The journal of allergy and clinical immunology. In practice · 2024Review
- Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study.Frontiers in pharmacology · 2024Article
- Measurement of adherence to inhaled corticosteroids by self-report and electronic medication monitoring.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Is Once Versus Twice Daily Dosing Better for Adherence in Asthma and Chronic Obstructive Pulmonary Disease?The journal of allergy and clinical immunology. In practice · 2023Article
- Asthma medication adherence and exacerbations and lung function in children managed in Leicester primary care.NPJ primary care respiratory medicine · 2023Review
- Asthma management and control in children, adolescents, and adults in 25 countries: a Global Asthma Network Phase I cross-sectional study.The Lancet. Global health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundInformation comparing subjective and objective measurements of adherence to study medications and the effects of adherence on treatment-related differences in asthma clinical trials are limited.
objectiveWe sought to compare subjective and objective measurements of children's adherence to inhaled corticosteroids or placebo and to determine whether adherence to study medications modified treatment-related differences in outcomes.
methodsIn an ancillary study conducted in 3 of 8 Childhood Asthma Management Program Clinical Centers, adherence was assessed by using self-reported and objective data in 5- to 12-year-old children with mild or moderate asthma who were randomly assigned to 200 μg of inhaled budesonide twice per day (n = 84) or placebo (n = 56) for 4 years. The κ statistic was used to evaluate agreement between self-reported adherence (daily diary cards) and objectively measured adherence (number of doses left in study inhalers). Multivariable analyses were used to determine whether adherence to study treatment modified treatment-related differences in outcomes.
resultsAdherence of less than 80% was seen in 75% of 140 children when adherence was measured objectively but only in 6% of children when measured by means of self-report. There was poor agreement between objective and subjective measurements of adherence of at least 80% (κ = 0.00; 95% CI, -0.05 to 0.04); self-reported adherence over the 4-year period generally overestimated objectively measured adherence (93.6% vs 60.8%, P < .0001). There was little evidence to indicate that adherence modified treatment-related differences in outcomes.
conclusionResearchers should use objective rather than self-reported adherence data to identify clinical trial participants with low levels of adherence to study treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.