ArticleGut1990
Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.
Article in Gut, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 68 citations in OpenAlex.
- Trial
- Current advantages in the application of proteomics in inflammatory bowel disease.Digestive diseases and sciences · 2012Review
- 18F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis.European journal of nuclear medicine and molecular imaging · 2009Article
- Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease.The American journal of gastroenterology · 2005Article
- Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis.Digestive diseases and sciences · 1996Article
- Soluble interleukin-2 receptor in Crohn's disease. Assessment of disease activity and prediction of relapse.Digestive diseases and sciences · 1995Article
- Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD).Clinical and experimental immunology · 1995Article
- Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease.Digestive diseases and sciences · 1995Article
- Review
- Article
- Increased spontaneous secretion of rheumatoid factor by intestinal lamina propria mononuclear cells from Crohn's disease but not ulcerative colitis patients.Clinical and experimental immunology · 1993Article
- Soluble interleukin-2 receptors in ulcerative colitis.Mediators of inflammation · 1993Article
- Article
- IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons.Clinical and experimental immunology · 1992Article
- Article
- Article
- Production of inflammatory cytokines in the intestinal lamina propria.Immunologic research · 1991Review
- Neutrophil autoantibodies as disease markers for ulcerative colitis.Immunologic research · 1991Review
- Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease.Immunologic research · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum concentrations of soluble interleukin-2 receptor (sIL-2R) were measured as a marker of immune activation in a group of 30 patients with Crohn's disease. sIL-2R concentrations were determined by enzyme linked immunosorbent assay during periods of active and inactive disease and correlated with standard parameters of disease activity. Serum concentrations of sIL-2R were significantly raised in patients with active Crohn's disease compared with patients with inactive disease (p less than 0.001) and control subjects. There was a significant correlation between serum sIL-2R concentrations and disease activity as assessed by the Harvey-Bradshaw index (r = 0.42, p less than 0.01), platelet numbers (r = 0.49, p less than 0.01), and orosomucoid (r = 0.47, p less than 0.01), alpha 1 antitrypsin (r = 0.44, p less than 0.01), and C reactive protein concentrations (r = 0.48, p less than 0.001) but not with the erythrocyte sedimentation rate. Measurement of serum sIL-2R concentration is a simple and useful laboratory means of assessing disease activity. Raised concentrations in patients with active Crohn's disease is further evidence for in vivo immune activation occurring in this disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.