ArticleAnesthesia and analgesia2012
Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.
Article in Anesthesia and analgesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Plasma pharmacokinetics of intravenous and intranasal oxytocin in nonpregnant adults.British journal of anaesthesia · 2025Trial
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.International journal of molecular sciences · 2023Article
- Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes.International journal of molecular sciences · 2022Article
- The Comprehensive Neural Mechanism of Oxytocin in Analgesia.Current neuropharmacology · 2022Review
- Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP.Nature reviews. Neurology · 2021Review
- Oxytocin Controls Chondrogenesis and Correlates with Osteoarthritis.International journal of molecular sciences · 2020Article
- DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models.Journal of pain research · 2020Article
- Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model.Experimental brain research · 2019Article
- Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation.Scientific reports · 2018Article
- Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Oxytocin, GABA, and TRPV1, the Analgesic Triad?Frontiers in molecular neuroscience · 2018Article
- Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.Neural plasticity · 2018Review
- The Analgesic Effect of Oxytocin in Humans: A Double-Blind, Placebo-Controlled Cross-Over Study Using Laser-Evoked Potentials.Journal of neuroendocrinology · 2016Article
- The role of nitric oxide on the oxytocin induce analgesia in mice.Iranian journal of basic medical sciences · 2016Article
- Oxytocin - a multifunctional analgesic for chronic deep tissue pain.Current pharmaceutical design · 2015Review
- Oxytocin and bone.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons.British journal of pharmacology · 2014Article
- Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism.Journal of physiology and biochemistry · 2014Article
- Platelet-rich plasma and the elimination of neuropathic pain.Molecular neurobiology · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
backgroundLumbar intrathecal injection of oxytocin produces antinociception in rats and analgesia in humans. Classically, oxytocin receptors couple to stimulatory G proteins, increase inositol-3-phosphate production, and result in neuronal excitation. Most work to date has focused on a spinal site of oxytocin to excite γ-aminobutyric acid interneurons to produce analgesia. Here we ask whether oxytocin might also affect primary sensory afferents by modulating high voltage-gated calcium channels, such as it does in the brain.
methodsDorsal root ganglion cells from adult rats were acutely dissociated and cultured, and changes in intracellular calcium determined by fluorescent microscopy using an indicator dye. The effects of oxytocin alone and in the presence of transient depolarization from increased extracellular KCl concentration were determined, and the pharmacology of these effects were studied. Cells from injured dorsal root ganglion cells after spinal nerve ligation were also studied.
resultsOxytocin produced a concentration-dependent inhibition of the increase in intracellular calcium from membrane depolarization, an effect blocked more efficiently by oxytocin- than vasopressin-receptor selective antagonists. Oxytocin-induced inhibition was present in cells responding to capsaicin, and when internal stores of calcium were depleted with thapsigargin. Oxytocin produced similar inhibition in cells from animals with spinal nerve ligation.
conclusionsThese data suggest that oxytocin produces antinociception after intrathecal delivery in part by reducing excitatory neurotransmitter release from the central terminals of nociceptors.
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