ReviewCongestive heart failure (Greenwich, Conn.)
Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.
Review in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway.Molecular medicine reports · 2026Article
- Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression.Renal failure · 2025Review
- PhosF3C: a feature fusion architecture with fine-tuned protein language model and conformer for prediction of general phosphorylation site.Briefings in bioinformatics · 2025Article
- Inefficient Batteries in Heart Failure: Metabolic Bottlenecks Disrupting the Mitochondrial Ecosystem.JACC. Basic to translational science · 2022Review
- High glucose induces phosphorylation and oxidation of mitochondrial proteins in renal tubular cells: A proteomics approach.Scientific reports · 2020Article
- Skeletal muscle bioenergetics in aging and heart failure.Heart failure reviews · 2017Review
- Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function.Cell reports · 2017Article
- Mitochondrial remodeling: Rearranging, recycling, and reprogramming.Cell calcium · 2016Review
- Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.Cell reports · 2016Article
- Mitochondrial involvement in myocyte death and heart failure.Heart failure reviews · 2016Review
- Post-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in Translation.Korean circulation journal · 2016Review
- Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure.Molecular and cellular biochemistry · 2014Article
- Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria.Frontiers in physiology · 2014Review
- An integrated mitochondrial ROS production and scavenging model: implications for heart failure.Biophysical journal · 2013Article
- Alterations in mitochondrial function in cardiac hypertrophy and heart failure.Heart failure reviews · 2013Review
- The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics.The Journal of cell biology · 2013Article
- Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.Physiological reports · 2013Article
- A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.Cell metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Phosphorylation of mitochondrial proteins has been recognized for decades, and the regulation of pyruvate- and branched-chain α-ketoacid dehydrogenases by an atypical kinase/phosphatase cascade is well established. More recently, the development of new mass spectrometry-based technologies has led to the discovery of many novel phosphorylation sites on a variety of mitochondrial targets. The evidence suggests that the major classes of kinase and several phosphatases may be present at the mitochondrial outer membrane, intermembrane space, inner membrane, and matrix, but many questions remain to be answered as to the location, timing, and reversibility of these phosphorylation events and whether they are functionally relevant. The authors review phosphorylation as a mitochondrial regulatory strategy and highlight its possible role in the pathophysiology of cardiac hypertrophy and failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.