ReviewCongestive heart failure (Greenwich, Conn.)
Proteomic remodeling of mitochondria in heart failure.
Review in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Heart Metabolism in Sepsis-Induced Cardiomyopathy-Unusual Metabolic Dysfunction of the Heart.International journal of environmental research and public health · 2021Review
- Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Melatonin Efficacy in Obese Leptin-Deficient Mice Heart.Nutrients · 2017Article
- Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart.Alcoholism, clinical and experimental research · 2017Article
- Calcineurin signaling in the heart: The importance of time and place.Journal of molecular and cellular cardiology · 2017Review
- Role of microRNA in metabolic shift during heart failure.American journal of physiology. Heart and circulatory physiology · 2017Review
- Post-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in Translation.Korean circulation journal · 2016Review
- Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.Heart failure reviews · 2015Review
- Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies.American journal of physiology. Heart and circulatory physiology · 2014Review
- Mitochondrial proteome remodeling in ischemic heart failure.Life sciences · 2014Article
- Characterization, design, and function of the mitochondrial proteome: from organs to organisms.Journal of proteome research · 2014Article
- Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart.Cardiovascular toxicology · 2013Article
- Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.Physiological reports · 2013Article
- αB-crystallin regulates oxidative stress-induced apoptosis in cardiac H9c2 cells via the PI3K/AKT pathway.Molecular biology reports · 2013Article
- Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation.The Journal of general physiology · 2012Article
- Differential regulation of EHD3 in human and mammalian heart failure.Journal of molecular and cellular cardiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Heart failure (HF) is a common disease that has been attributed, in part, to deprivation of cardiac energy. As a result, the interplay between metabolism and adenosine triphosphate production is fundamental in determining the mechanisms driving the disease progression. Due to its central role in energy production, metabolism, calcium homeostasis, and oxidative stress, the mitochondrion has been suggested to play a pivotal role in the progression of the heart to failure. Nevertheless, the mitochondrion's specific role(s) and the proteins contributing to the development and progression of HF are not entirely clear. Thus, changes in mitochondrial proteomic make-up during HF have garnered great interest. With the continued development of advanced tools for assessing proteomic make-up, characterization of mitochondrial proteomic changes during disease states such as HF are being realized. These studies have begun to identify potential biomarkers of disease progression as well as protein targets that may provide an avenue for therapeutic intervention. The goal of this review is to highlight some of the changes in mitochondrial proteomic make-up that are associated with the development of HF in an effort to identify target axes and candidate proteins contributing to disease development. Results from a number of different HF models will be evaluated to gain insight into some of the similarities and differences in mitochondrial proteomic alterations associated with morphological and functional changes that result from the disease. Congest Heart Fail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.