ArticleJournal of the American Chemical Society2012
Three-component coupling sequence for the regiospecific synthesis of substituted pyridines.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Exploring the Potential of Pyridine Carboxylic Acid Isomers to Discover New Enzyme Inhibitors.Drug design, development and therapy · 2025Review
- The Corey-Seebach Reagent in the 21st Century: A Review.Molecules (Basel, Switzerland) · 2023Review
- Article
- Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Reactions of 2-Aryl-1,3-Dithianes and [1.1.1]Propellane.Angewandte Chemie (International ed. in English) · 2019Article
- Dithiane-directed Rh(iii)-catalyzed amidation of unactivated C(spChemical science · 2019Article
- Dative Directing Group Effects in Ti-Catalyzed [2+2+1] Pyrrole Synthesis: Chemo- and Regioselective Alkyne Heterocoupling.ACS catalysis · 2019Article
- Modern applications of low-valent early transition metals in synthesis and catalysis.Nature reviews. Chemistry · 2019Article
- Domino Reaction Sequence for the Synthesis of [2.2.2]Diazabicycloalkenes and Base-Promoted Cycloreversion to 2-Pyridone Alkaloids.Organic letters · 2018Article
- Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes.The Journal of organic chemistry · 2018Article
- Synthesis of Highly Oxygenated Carbocycles by Stereoselective Coupling of Alkynes to 1,3- and 1,4-Dicarbonyl Systems.Journal of the American Chemical Society · 2017Article
- (2S,4E)-2-Hydroxy-4-octen-3-one, a Male-Produced Attractant Pheromone of the Cerambycid Beetle Tylonotus bimaculatus.Journal of chemical ecology · 2015Article
- Reaction design, discovery, and development as a foundation to function-oriented synthesis.Accounts of chemical research · 2015Article
- Copper-mediated synthesis of N-alkenyl-α,β-unsaturated nitrones and their conversion to tri- and tetrasubstituted pyridines.Beilstein journal of organic chemistry · 2015Article
- Rh(III)-catalyzed decarboxylative coupling of acrylic acids with unsaturated oxime esters: carboxylic acids serve as traceless activators.Journal of the American Chemical Society · 2014Article
- The Flögel-three-component reaction with dicarboxylic acids - an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives.Beilstein journal of organic chemistry · 2014Article
- Rh(III)-catalyzed regioselective synthesis of pyridines from alkenes and α,β-unsaturated oxime esters.Journal of the American Chemical Society · 2013Article
- Highly diastereoselective synthesis of tetrahydropyridines by a C-H activation-cyclization-reduction cascade.Journal of the American Chemical Society · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
A de novo synthesis of substituted pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an α,β-unsaturated carbonyl followed by metallacycle-mediated union of the resulting allylic alcohol with preformed trimethylsilane-imines (generated in situ by the low-temperature reaction of lithium hexamethyldisilazide with an aldehyde) and Ag(I)- or Hg(II)-mediated ring closure. The process is useful for the convergent assembly of di- through penta-substituted pyridines with complete regiochemical control.
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Registered trials
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