ReviewBiomarkers in medicine2011
Energy metabolism in nuclear reprogramming.
Review in Biomarkers in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Alterations in energy expenditure and muscle performance following short-term muscle immobilization and rehabilitative exercise in mice.Physical activity and nutrition · 2025Article
- Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency.Experimental & molecular medicine · 2025Article
- Article
- Role of Diet in Stem and Cancer Stem Cells.International journal of molecular sciences · 2022Review
- Metabolic Requirements for Spermatogonial Stem Cell Establishment and Maintenance In Vivo and In Vitro.International journal of molecular sciences · 2021Review
- Malignancy prediction among tissues from Oral SCC patients including neck invasions: aMetabolomics : Official journal of the Metabolomic Society · 2020Article
- Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.Nature communications · 2019Article
- Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.Journal of cell science · 2018Article
- Pharmacological Regulation of Oxidative Stress in Stem Cells.Oxidative medicine and cellular longevity · 2018Review
- Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation.Scientific reports · 2017Article
- Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw.Stem cell research & therapy · 2016Article
- Article
- Article
- GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells.Scientific reports · 2015Article
- Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma.Cell cycle (Georgetown, Tex.) · 2015Article
- Metabolic control of cancer cell stemness: Lessons from iPS cells.Cell cycle (Georgetown, Tex.) · 2015Review
- Metabolic determinants of embryonic development and stem cell fate.Reproduction, fertility, and development · 2014Review
- Cancer stem cell theory and the warburg effect, two sides of the same coin?International journal of molecular sciences · 2014Article
- Metabostemness: a new cancer hallmark.Frontiers in oncology · 2014Review
- Metformin against cancer stem cells through the modulation of energy metabolism: special considerations on ovarian cancer.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Nuclear reprogramming with stemness factors enables resetting of somatic differentiated tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial restructuring and bioenergetic plasticity as key components underlying execution of orchestrated dedifferentiation and derivation of induced pluripotent stem cells. Aerobic to anaerobic transition of somatic oxidative energy metabolism into a glycolytic metabotype promotes proficient reprogramming, establishing a novel regulator of acquired stemness. Metabolomic profiling has further identified specific metabolic remodeling traits defining lineage redifferentiation of pluripotent cells. Therefore, mitochondrial biogenesis and energy metabolism comprise a vital axis for biomarker discovery, intimately reflecting the molecular dynamics fundamental for the resetting and redirection of cell fate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.