ArticleFrontiers in integrative neuroscience2011
Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation.
Article in Frontiers in integrative neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- The Brain Basis of Positive and Negative Affect: Evidence from a Meta-Analysis of the Human Neuroimaging Literature.Cerebral cortex (New York, N.Y. : 1991) · 2016Pooled it
- Common brain activations for painful and non-painful aversive stimuli.BMC neuroscience · 2012Pooled it
- GABAA receptors predict aversion-related brain responses: an fMRI-PET investigation in healthy humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli.Obesity (Silver Spring, Md.) · 2026Article
- Ferroptosis inhibitor UAMC-3203 preserves memory and prevents anxiety-like behavior but worsens aversive learning in diabetic rats after stroke in a randomized preclinical trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Chronic dizziness: neuro-sensitization and psycho-sensitization.Frontiers in integrative neuroscience · 2026Review
- Deciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes.Human brain mapping · 2025Article
- Visual cortex repetitive transcranial magnetic stimulation (rTMS) reversing neurodevelopmental impairments in adolescents with major psychiatric disorders (MPDs): A cross-species translational study.CNS neuroscience & therapeutics · 2024Article
- Article
- Functional and structural networks decoupling in generalized tonic-clonic seizures and its reorganization by drugs.Epilepsia open · 2023Article
- Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Brain 5-HTBrain imaging and behavior · 2022Article
- Common and stimulus-type-specific brain representations of negative affect.Nature neuroscience · 2022Article
- Assessing Multisensory Sensitivity Across Scales: Using the Resulting Core Factors to Create the Multisensory Amplification Scale.The journal of pain · 2022Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Affective Enhancement of Episodic Memory Is Associated With Widespread Patterns of Intrinsic Functional Connectivity in the Brain Across the Adult Lifespan.Frontiers in behavioral neuroscience · 2022Article
- Whole-Brain Monosynaptic Afferents to Rostromedial Tegmental Nucleus Gamma-Aminobutyric Acid-Releasing Neurons in Mice.Frontiers in neuroscience · 2022Article
- Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.Frontiers in human neuroscience · 2022Article
- Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex: An fMRI study with healthy adults.Human brain mapping · 2021Article
- Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction.Addiction biology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of various cortical regions, such as the prefrontal cortex, while animal studies have focused largely on subcortical regions like the periaqueductal gray and hypothalamus. However, whether and how these regions form a core neural network of aversion remains unclear. To help determine this, a translational cross-species investigation in humans (i.e., meta-analysis) and other animals (i.e., systematic review of functional neuroanatomy) was performed. Our results highlighted the recruitment of the anterior cingulate cortex, the anterior insula, and the amygdala as well as other subcortical (e.g., thalamus, midbrain) and cortical (e.g., orbitofrontal) regions in both animals and humans. Importantly, involvement of these regions remained independent of sensory modality. This study provides evidence for a core neural network mediating aversion in both animals and humans. This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behavior can often be observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.