ArticlePLoS computational biology2011
A density-dependent switch drives stochastic clustering and polarization of signaling molecules.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Article
- Computational Tools for Handling Molecular Clusters: Configurational Sampling, Storage, Analysis, and Machine Learning.ACS omega · 2023Article
- A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit.Cell reports · 2023Article
- Particle-based simulations reveal two positive feedback loops allow relocation and stabilization of the polarity site during yeast mating.PLoS computational biology · 2023Article
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Oligomerization of peripheral membrane proteins provides tunable control of cell surface polarity.Biophysical journal · 2022Article
- Orientation of Cell Polarity by Chemical Gradients.Annual review of biophysics · 2022Review
- A positive feedback loop involving the Spa2 SHD domain contributes to focal polarization.PloS one · 2022Article
- A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.PLoS computational biology · 2021Article
- Coordinating cell polarization and morphogenesis through mechanical feedback.PLoS computational biology · 2021Article
- Mechanistic insights into actin-driven polarity site movement in yeast.Molecular biology of the cell · 2020Article
- Stochastic activation and bistability in a Rab GTPase regulatory network.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Interplay of Structural and Cellular Biophysics Controls Clustering of Multivalent Molecules.Biophysical journal · 2019Article
- Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks.PLoS computational biology · 2018Article
- The effect of cell geometry on polarization in budding yeast.PLoS computational biology · 2018Article
- Particle-based simulations of polarity establishment reveal stochastic promotion of Turing pattern formation.PLoS computational biology · 2018Article
- A model of cell surface receptor aggregation.Journal of mathematical biology · 2017Article
- A microtubule-based minimal model for spontaneous and persistent spherical cell polarity.PloS one · 2017Article
- Numerical Approach to Spatial Deterministic-Stochastic Models Arising in Cell Biology.PLoS computational biology · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
Positive feedback plays a key role in the ability of signaling molecules to form highly localized clusters in the membrane or cytosol of cells. Such clustering can occur in the absence of localizing mechanisms such as pre-existing spatial cues, diffusional barriers, or molecular cross-linking. What prevents positive feedback from amplifying inevitable biological noise when an un-clustered "off" state is desired? And, what limits the spread of clusters when an "on" state is desired? Here, we show that a minimal positive feedback circuit provides the general principle for both suppressing and amplifying noise: below a critical density of signaling molecules, clustering switches off; above this threshold, highly localized clusters are recurrently generated. Clustering occurs only in the stochastic regime, suggesting that finite sizes of molecular populations cannot be ignored in signal transduction networks. The emergence of a dominant cluster for finite numbers of molecules is partly a phenomenon of random sampling, analogous to the fixation or loss of neutral mutations in finite populations. We refer to our model as the "neutral drift polarity model." Regulating the density of signaling molecules provides a simple mechanism for a positive feedback circuit to robustly switch between clustered and un-clustered states. The intrinsic ability of positive feedback both to create and suppress clustering is a general mechanism that could operate within diverse biological networks to create dynamic spatial organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.