ArticleJournal of immunology (Baltimore, Md. : 1950)2011
BAFF/APRIL inhibition decreases selection of naive but not antigen-induced autoreactive B cells in murine systemic lupus erythematosus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Context-dependent induction of autoimmunity by TNF signaling deficiency.JCI insight · 2022Article
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.Frontiers in immunology · 2022Review
- Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies.Trends in molecular medicine · 2021Review
- Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus.International journal of molecular sciences · 2019Review
- BAFF inhibition in SLE-Is tolerance restored?Immunological reviews · 2019Review
- Patterns of ANA+ B cells for SLE patient stratification.JCI insight · 2019Article
- Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients.JCI insight · 2018Article
- The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus.Molecular medicine (Cambridge, Mass.) · 2016Article
- Defects in Germinal Center Selection in SLE.Frontiers in immunology · 2015Review
- TLR7 influences germinal center selection in murine SLE.PloS one · 2015Article
- Structure and function of renal macrophages and dendritic cells from lupus-prone mice.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- The Yaa locus and IFN-α fine-tune germinal center B cell selection in murine systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The rationale for BAFF inhibition in systemic lupus erythematosus.Current rheumatology reports · 2012Review
- Autoimmunity in 2011.Clinical reviews in allergy & immunology · 2012Review
- B cell tolerance and positive selection in lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Connective tissue diseases: Autoreactive B cells evade BAFF blockade in a mouse model of SLE.Nature reviews. Rheumatology · 2011Article
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Abstract
BAFF inhibition is a new B cell-directed therapeutic strategy for autoimmune disease. Our purpose was to analyze the effect of BAFF/APRIL availability on the naive and Ag-activated B cell repertoires in systemic lupus erythematosus, using the autoreactive germline D42 H chain (glD42H) site-directed transgenic NZB/W mouse. In this article, we show that the naive Vκ repertoire in both young and diseased glD42H NZB/W mice is dominated by five L chains that confer no or low-affinity polyreactivity. In contrast, glD42H B cells expressing L chains that confer high-affinity autoreactivity are mostly deleted before the mature B cell stage, but are positively selected and expanded in the germinal centers (GCs) as the mice age. Of these, the most abundant is VκRF (Vκ16-104*01), which is expressed by almost all IgG anti-DNA hybridomas derived from the glD42H mouse. Competition with nonautoreactive B cells or BAFF/APRIL inhibition significantly inhibited selection of glD42H B cells at the late transitional stage, with only subtle effects on the glD42H-associated L chain repertoire. However, glD42H/VκRF-encoded B cells were still vastly overrepresented in the GC, and serum IgG anti-DNA Abs arose with only a slight delay. Thus, although BAFF/APRIL inhibition increases the stringency of negative selection of the naive autoreactive B cell repertoire in NZB/W mice, it does not correct the major breach in B cell tolerance that occurs at the GC checkpoint.
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