ArticleNucleic acids research2012
COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
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- Literature-based translation from synthetic lethality screening into therapeutics targets: CD82 is a novel target forComputational and structural biotechnology journal · 2022Article
- A network of human functional gene interactions from knockout fitness screens in cancer cells.Life science alliance · 2019Article
- NetControl4BioMed: a pipeline for biomedical data acquisition and analysis of network controllability.BMC bioinformatics · 2018Article
- A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.Nature genetics · 2018Article
- A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification.BMC genomics · 2018Article
- A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.Cell systems · 2017Article
- Controlling Directed Protein Interaction Networks in Cancer.Scientific reports · 2017Article
- Network Analysis Reveals A Signaling Regulatory Loop in the PIK3CA-mutated Breast Cancer Predicting Survival Outcome.Genomics, proteomics & bioinformatics · 2017Article
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- Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.Genes & development · 2016Article
- Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.Disease models & mechanisms · 2016Article
- Public data and open source tools for multi-assay genomic investigation of disease.Briefings in bioinformatics · 2016Review
- Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.Genome biology · 2016Article
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Cell reports · 2016Article
- ApoCanD: Database of human apoptotic proteins in the context of cancer.Scientific reports · 2016Article
- An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.Molecular oncology · 2016Article
- dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Genome-wide pooled shRNA screens enable global identification of the genes essential for cancer cell survival and proliferation and provide a 'functional genetic' map of human cancer to complement genomic studies. Using a lentiviral shRNA library targeting approximately 16,000 human genes and a newly developed scoring approach, we identified essential gene profiles in more than 70 breast, pancreatic and ovarian cancer cell lines. We developed a web-accessible database system for capturing information from each step in our standardized screening pipeline and a gene-centric search tool for exploring shRNA activities within a given cell line or across multiple cell lines. The database consists of a laboratory information and management system for tracking each step of a pooled shRNA screen as well as a web interface for querying and visualization of shRNA and gene-level performance across multiple cancer cell lines. COLT-Cancer Version 1.0 is currently accessible at http://colt.ccbr.utoronto.ca/cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.