ReviewStem cells (Dayton, Ohio)2012
Concise review: Inner ear stem cells--an oxymoron, but why?
Review in Stem cells (Dayton, Ohio), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- No systemic exposure of transtympanic heparin-binding epidermal growth factor like growth factor.Drug and chemical toxicology · 2016Article
- Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells.Journal of visualized experiments : JoVE · 2016Article
- Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells.Frontiers in cellular neuroscience · 2016Article
- Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways.Developmental cell · 2015Article
- Genome-wide demethylation by 5-aza-2'-deoxycytidine alters the cell fate of stem/progenitor cells.Stem cell reviews and reports · 2015Article
- Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells.Cellular reprogramming · 2014Article
- Bilateral Vestibular Deficiency: Quality of Life and Economic Implications.JAMA otolaryngology-- head & neck surgery · 2014Article
- Review
- Grafting and early expression of growth factors from adipose-derived stem cells transplanted into the cochlea, in a Guinea pig model of acoustic trauma.Frontiers in cellular neuroscience · 2014Article
- Changes in the adult vertebrate auditory sensory epithelium after trauma.Hearing research · 2013Review
- A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis.PloS one · 2013Article
- Article
- The myc road to hearing restoration.Cells · 2012Article
- Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Cell and tissue research · 2012Review
- In vivo proliferative regeneration of balance hair cells in newborn mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hearing loss, caused by irreversible loss of cochlear sensory hair cells, affects millions of patients worldwide. In this concise review, we examine the conundrum of inner ear stem cells, which obviously are present in the inner ear sensory epithelia of nonmammalian vertebrates, giving these ears the ability to functionally recover even from repetitive ototoxic insults. Despite the inability of the mammalian inner ear to regenerate lost hair cells, there is evidence for cells with regenerative capacity because stem cells can be isolated from vestibular sensory epithelia and from the neonatal cochlea. Challenges and recent progress toward identification of the intrinsic and extrinsic signaling pathways that could be used to re-establish stemness in the mammalian organ of Corti are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.