ArticleHuman brain mapping2013
Functional connectivity during recognition memory in individuals genetically at risk for Alzheimer's disease.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Differential Effects of BMI on Brain Response to Odor in Olfactory, Reward and Memory Regions: Evidence from fMRI.Nutrients · 2019Trial
- Brain activation in older adults during odor identification is related to ApoE, t-tau/AβNeurobiology of aging · 2025Article
- The effect of the apolipoprotein E ε4 allele and olfactory function on odor identification networks.Brain and behavior · 2024Article
- Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum.Frontiers in neuroscience · 2024Review
- Olfactory Measures as Predictors of Conversion to Mild Cognitive Impairment and Alzheimer's Disease.Brain sciences · 2021Article
- Older, non-demented apolipoprotein εNeurobiology of aging · 2020Article
- The Brief Form of the California Odor Learning Test 3.Frontiers in neuroscience · 2020Article
- Effect of Worry Level on Recall Memory for Odors in ApoE-ε4 Carriers and Non-Carriers.Journal of the International Neuropsychological Society : JINS · 2019Article
- Olfactory and other sensory impairments in Alzheimer disease.Nature reviews. Neurology · 2019Review
- At the interface of sensory and motor dysfunctions and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers.Cortex; a journal devoted to the study of the nervous system and behavior · 2014Article
- Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.Brain imaging and behavior · 2014Review
- Abnormal intrinsic brain activity patterns in patients with subcortical ischemic vascular dementia.PloS one · 2014Article
- Article
- Olfactory ERPs in an odor/visual congruency task differentiate ApoE ε4 carriers from non-carriers.Brain research · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The medial temporal lobes (MTL) and frontal cortex have been shown to subserve memory processes. Neurodegenerative diseases, such as Alzheimer's disease (AD), disrupt the neuronal networks that underlie memory processing. The ε4 allele of the apolipoprotein E gene is a genetic risk factor for AD and is associated with decrements in memory and in olfactory function. The present study utilized EQS, a structural equation modeling software program, to examine differences in the neuronal networks between non-demented ε4 carriers and ε4 noncarriers during a cross-modal olfactory recognition memory paradigm. Prior to fMRI scanning, participants were presented with 16 odors. During two scans, participants discriminated between names of odors presented before scanning (targets) or not presented (foils). The results indicate significant connections between bilateral frontal lobes and MTL for ε4 carriers when they misidentified a foil as a target. When ε4 noncarriers correctly identified a target, there were greater associations between the amygdala, MTL, and right frontal lobe; these associations also modeled the brain's response when ε4 noncarriers misidentified a foil as a target. During memory retrieval, affective cues may facilitate retrieval in ε4 noncarriers relative to ε4 carriers. Last, no model was found that best represented the functional network used by ε4 carriers when they correctly identified a target, which may reflect variability of neuronal recruitment within this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.